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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 ACS+Med+Chem+Lett 2010 ; 2 (1): 48-52 Nephropedia Template TP
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Structure-Activity Relationships at the Monoamine Transporters for a Novel Series of Modafinil (2- (diphenylmethyl)sulfinyl acetamide) Analogues #MMPMID21344069
Cao J; Prisinzano TE; Okunola OM; Kopajtic T; Shook M; Katz JL; Newman AH
ACS Med Chem Lett 2010[Oct]; 2 (1): 48-52 PMID21344069show ga
A series of modafinil (1) analogues was synthesized wherein 1) para-halo-substitutents were added to the aryl rings, 2) the sulfoxide function was removed, and 3) the primary amide group was replaced with secondary and tertiary amides and amines to investigate the effects of these chemical modifications on DAT, SERT and NET binding. In addition, the locomotor-stimulant effects in mice of (+/-)-modafinil (1), its R- and S-enantiomers and its para-chloro sulfinylacetamide analogue (5c) were compared to those of cocaine.