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10.1021/ml1002025

http://scihub22266oqcxt.onion/10.1021/ml1002025
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suck abstract from ncbi


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pmid21344069      ACS+Med+Chem+Lett 2010 ; 2 (1): 48-52
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  • Structure-Activity Relationships at the Monoamine Transporters for a Novel Series of Modafinil (2- (diphenylmethyl)sulfinyl acetamide) Analogues #MMPMID21344069
  • Cao J; Prisinzano TE; Okunola OM; Kopajtic T; Shook M; Katz JL; Newman AH
  • ACS Med Chem Lett 2010[Oct]; 2 (1): 48-52 PMID21344069show ga
  • A series of modafinil (1) analogues was synthesized wherein 1) para-halo-substitutents were added to the aryl rings, 2) the sulfoxide function was removed, and 3) the primary amide group was replaced with secondary and tertiary amides and amines to investigate the effects of these chemical modifications on DAT, SERT and NET binding. In addition, the locomotor-stimulant effects in mice of (+/-)-modafinil (1), its R- and S-enantiomers and its para-chloro sulfinylacetamide analogue (5c) were compared to those of cocaine.
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