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10.4196/kjpp.2010.14.6.377 http://scihub22266oqcxt.onion/10.4196/kjpp.2010.14.6.377 21311678!3034117!21311678     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21311678&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Korean+J+Physiol+Pharmacol 2010 ; 14 (6): 377-84 Nephropedia Template TP {{tp|p=21311678|t=2010. Metformin Inhibits Isoproterenol-induced Cardiac Hypertrophy in Mice |pdf=|usr=}}{{21311678}} gab.com Text Metformin Inhibits Isoproterenol-induced Cardiac Hypertrophy in Mice JO: Korean J Physiol Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=21311678 #FOAvip The present study examined whether metformin treatment prevents isoporterenol-induced cardiac hypertrophy in mice. Chronic subcutaneous infusion of isoproterenol (15 mg/kg/24 h) for 1 week using an osmotic minipump induced cardiac hypertrophy measured by the heart-to-body weight ratio and left ventricular posterior wall thickness. Cardiac hypertrophy was accompanied with increased interleukin-6 (IL-6), transforming growth factor (TGF)-beta, atrial natriuretic peptide (ANP), collagen I and III, and matrix metallopeptidase 2 (MMP-2). Coinfusion of metformin (150 mg/kg/24 h) with isoproterenol partially inhibited cardiac hypertrophy that was followed by reduced IL-6, TGF-beta, ANP, collagen I and III, and MMP-2. Chronic subcutaneous infusion of metformin did not increase AMP-activated protein kinase (AMPK) activity in heart, although acute intraperitoneal injection of metformin (10 mg/kg) increased AMPK activity. Isoproterenol increased nitrotyrosine levels and mRNA expression of antioxidant enzyme glutathione peroxidase and metformin treatment normalized these changes. These results suggest that metformin inhibits cardiac hypertrophy through attenuating oxidative stress. Twit Text FOAVip Metformin Inhibits Isoproterenol-induced Cardiac Hypertrophy in Mice ????Korean J Physiol Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=21311678 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21311678 #FOAvip English Wikipedia <ref>{{Cite pmid|21311678}}</ref> Metformin Inhibits Isoproterenol-induced Cardiac Hypertrophy in Mice #MMPMID21311678 Cha HN; Choi JH; Kim YW; Kim JY; Ahn MW; Park SY Korean J Physiol Pharmacol 2010[Dec]; 14 (6): 377-84 PMID21311678show ga The present study examined whether metformin treatment prevents isoporterenol-induced cardiac hypertrophy in mice. Chronic subcutaneous infusion of isoproterenol (15 mg/kg/24 h) for 1 week using an osmotic minipump induced cardiac hypertrophy measured by the heart-to-body weight ratio and left ventricular posterior wall thickness. Cardiac hypertrophy was accompanied with increased interleukin-6 (IL-6), transforming growth factor (TGF)-beta, atrial natriuretic peptide (ANP), collagen I and III, and matrix metallopeptidase 2 (MMP-2). Coinfusion of metformin (150 mg/kg/24 h) with isoproterenol partially inhibited cardiac hypertrophy that was followed by reduced IL-6, TGF-beta, ANP, collagen I and III, and MMP-2. Chronic subcutaneous infusion of metformin did not increase AMP-activated protein kinase (AMPK) activity in heart, although acute intraperitoneal injection of metformin (10 mg/kg) increased AMPK activity. Isoproterenol increased nitrotyrosine levels and mRNA expression of antioxidant enzyme glutathione peroxidase and metformin treatment normalized these changes. These results suggest that metformin inhibits cardiac hypertrophy through attenuating oxidative stress. ?Metformin Inhibits Isoproterenol-induced Cardiac Hypertrophy in Mice (epmc).pdf DeepDyve Pubget Overpricing