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suck abstract from ncbi

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  • Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia #MMPMID21289065
  • Wallingford JB; Mitchell B
  • Genes Dev 2011[Feb]; 25 (3): 201-13 PMID21289065show ga
  • Cilia are important cellular structures that have been implicated in a variety of signaling cascades. In this review, we discuss the current evidence for and against a link between cilia and both the canonical Wnt/beta-catenin pathway and the noncanonical Wnt/planar cell polarity (PCP) pathway. Furthermore, we address the evidence implicating a role for PCP components in ciliogenesis. Given the lack of consensus in the field, we use new data on the control of ciliary protein localization as a basis for proposing new models by which cell type-specific regulation of ciliary components via differential transport, regulated entry and exit, or diffusion barriers might generate context-dependent functions for cilia.
  • |*Signal Transduction[MESH]
  • |Animals[MESH]
  • |Cell Polarity/*physiology[MESH]
  • |Cilia/metabolism/*physiology[MESH]
  • |Humans[MESH]
  • |Protein Transport[MESH]
  • |Wnt Proteins/*metabolism[MESH]
  • |beta Catenin/metabolism[MESH]

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  • suck abstract from ncbi

    201 3.25 2011