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10.1016/j.imlet.2011.01.003 http://scihub22266oqcxt.onion/10.1016/j.imlet.2011.01.003 21256160!ä!21256160 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunol+Lett 2011 ; 136 (2): 138-45 Nephropedia Template TP {{tp|p=21256160|t=2011. Induction of heme oxygenase-1 expression by cilostazol contributes to its anti-inflammatory effects in J774 murine macrophages |pdf=|usr=}}{{21256160}} gab.com Text Induction of heme oxygenase-1 expression by cilostazol contributes to its anti-inflammatory effects in J774 murine macrophages JO: Immunol Lett http://www.kidney.de/pget.php?&tw=1&pmid=21256160 #FOAvip The effects of cilostazol on stimulating heme oxygenase (HO)-1 expression including signal pathways and suppression of inflammatory cytokines and molecules were studied. Cilostazol stimulation time (1-8 h)- and concentration (1-30 muM)-dependently increased the HO-1 mRNA and protein expression associated with increased HO-1 activity, as did cobalt protoporphyrin IX (1-3 muM) in J774 macrophages. In addition, cilostazol (1-30 muM) concentration-dependently reduced lipopolysaccharide (LPS)-mediated nitrite and TNF-alpha production, in accordance with the inhibition of LPS-stimulated inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expression in the J774 macrophages, as did CoPP (1 muM). In parallel with these results, LPS-induced IkappaBalpha degradation and NF-kappaB nuclear translocation were significantly decreased after treatment with cilostazol as well as with CoPP. These effects of cilostazol and CoPP were significantly reversed by Zn protoporphyrin IX (ZnPP). The effects of cilostazol on IkappaBalpha expression and nitrite production were not manifested in the cells transfected with HO-1 small interfering RNA. In the J774 macrophages, cilostazol time (0-180min)- and concentration (1-100muM)-dependently increased the nuclear expression of NF-E2 related factor (Nrf2) and antioxidant response element (ARE) activity (3.70+/-0.45 fold, P<0.01). PI3-kinase and Akt play a role in the major signal pathways with cilostazol-induced HO-1 expression. In summary, cilostazol suppressed production of anti-inflammatory cytokines and molecules via inhibition of NF-kappaB activation, through a mechanism involving up-regulation of cyclic AMP-dependent protein kinase activation-coupled Nrf2-linked HO-1 expression in J774A.1 macrophages. Twit Text FOAVip Induction of heme oxygenase-1 expression by cilostazol contributes to its anti-inflammatory effects in J774 murine macrophages ????Immunol Lett http://www.kidney.de/pget.php?&tw=1&pmid=21256160 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21256160 #FOAvip English Wikipedia <ref>{{Cite pmid|21256160}}</ref> Induction of heme oxygenase-1 expression by cilostazol contributes to its anti-inflammatory effects in J774 murine macrophages #MMPMID21256160 Park SY; Lee SW; Baek SH; Lee SJ; Lee WS; Rhim BY; Hong KW; Kim CD Immunol Lett 2011[May]; 136 (2): 138-45 PMID21256160show ga The effects of cilostazol on stimulating heme oxygenase (HO)-1 expression including signal pathways and suppression of inflammatory cytokines and molecules were studied. Cilostazol stimulation time (1-8 h)- and concentration (1-30 muM)-dependently increased the HO-1 mRNA and protein expression associated with increased HO-1 activity, as did cobalt protoporphyrin IX (1-3 muM) in J774 macrophages. In addition, cilostazol (1-30 muM) concentration-dependently reduced lipopolysaccharide (LPS)-mediated nitrite and TNF-alpha production, in accordance with the inhibition of LPS-stimulated inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expression in the J774 macrophages, as did CoPP (1 muM). In parallel with these results, LPS-induced IkappaBalpha degradation and NF-kappaB nuclear translocation were significantly decreased after treatment with cilostazol as well as with CoPP. These effects of cilostazol and CoPP were significantly reversed by Zn protoporphyrin IX (ZnPP). The effects of cilostazol on IkappaBalpha expression and nitrite production were not manifested in the cells transfected with HO-1 small interfering RNA. In the J774 macrophages, cilostazol time (0-180min)- and concentration (1-100muM)-dependently increased the nuclear expression of NF-E2 related factor (Nrf2) and antioxidant response element (ARE) activity (3.70+/-0.45 fold, P<0.01). PI3-kinase and Akt play a role in the major signal pathways with cilostazol-induced HO-1 expression. In summary, cilostazol suppressed production of anti-inflammatory cytokines and molecules via inhibition of NF-kappaB activation, through a mechanism involving up-regulation of cyclic AMP-dependent protein kinase activation-coupled Nrf2-linked HO-1 expression in J774A.1 macrophages. |Animals[MESH] |Anti-Inflammatory Agents/*pharmacology[MESH] |Cell Line[MESH] |Cilostazol[MESH] |Cyclooxygenase 2/genetics/metabolism[MESH] |Enzyme Activation/drug effects[MESH] |Gene Expression Regulation/*drug effects[MESH] |Heme Oxygenase-1/*genetics/*metabolism[MESH] |Lipopolysaccharides/metabolism[MESH] |Macrophages/*drug effects/*enzymology[MESH] |Mice[MESH] |NF-E2-Related Factor 2/metabolism[MESH] |NF-kappa B/antagonists & inhibitors[MESH] |Nitric Oxide Synthase Type II/genetics/metabolism[MESH] |Nitrites/metabolism[MESH] |Phosphatidylinositol 3-Kinases/metabolism[MESH] |Proto-Oncogene Proteins c-akt/metabolism[MESH] |Signal Transduction/drug effects[MESH] |Tetrazoles/*pharmacology[MESH]Induction of heme oxygenase-1 expression by cilostazol contributes to (epmc).pdf DeepDyve Pubget Overpricing