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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Magnes+Trace+Elem 1990 ; 9 (3): 163-75 Nephropedia Template TP
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Sodium-calcium exchange mechanism in vascular smooth muscle tissue as revealed by manipulating external magnesium #MMPMID2123389
Altura BT; Zhang AM; Altura BM
Magnes Trace Elem 1990[]; 9 (3): 163-75 PMID2123389show ga
Small reductions in external sodium ions [( Na+]o), which cause no contractile effects in normal Mg2(+)-containing medium, cause an immediate contraction when [Mg2+]o is simultaneously withdrawn from isolated rat aortic smooth muscle. These contractions are Ca2(+)-dependent and vary in magnitude with the extracellular Na concentration and the Na substitute used. In contrast to substitution with sucrose, mannitol, urea and choline, substitution with Tris or Li+ does not result in contractions, in the absence of [Mg2+]o with these comparatively low [Na+]o reductions. Choline, mannitol, sucrose and urea substitutions sometimes give rise to a fast contractile phase in the presence of [Mg2+]o, which relaxes within a short time (about 5 min). The rises in tension in response to lowering of [Na+]o in the absence of [Mg2+]o are inhibited by the Na+ influx blocker, amiloride. These data are compatible with the hypothesis that Mg2+ controls Na+/Ca2+ exchange in these low Na+ substitution experiments and also protects the cell from osmotically induced small changes in cell volume in rat aortic smooth muscle.