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suck abstract from ncbi


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pmid2123389      Magnes+Trace+Elem 1990 ; 9 (3): 163-75
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  • Sodium-calcium exchange mechanism in vascular smooth muscle tissue as revealed by manipulating external magnesium #MMPMID2123389
  • Altura BT; Zhang AM; Altura BM
  • Magnes Trace Elem 1990[]; 9 (3): 163-75 PMID2123389show ga
  • Small reductions in external sodium ions [( Na+]o), which cause no contractile effects in normal Mg2(+)-containing medium, cause an immediate contraction when [Mg2+]o is simultaneously withdrawn from isolated rat aortic smooth muscle. These contractions are Ca2(+)-dependent and vary in magnitude with the extracellular Na concentration and the Na substitute used. In contrast to substitution with sucrose, mannitol, urea and choline, substitution with Tris or Li+ does not result in contractions, in the absence of [Mg2+]o with these comparatively low [Na+]o reductions. Choline, mannitol, sucrose and urea substitutions sometimes give rise to a fast contractile phase in the presence of [Mg2+]o, which relaxes within a short time (about 5 min). The rises in tension in response to lowering of [Na+]o in the absence of [Mg2+]o are inhibited by the Na+ influx blocker, amiloride. These data are compatible with the hypothesis that Mg2+ controls Na+/Ca2+ exchange in these low Na+ substitution experiments and also protects the cell from osmotically induced small changes in cell volume in rat aortic smooth muscle.
  • |Amiloride/pharmacology[MESH]
  • |Animals[MESH]
  • |Aorta[MESH]
  • |Calcium Chloride/pharmacology[MESH]
  • |Calcium/*metabolism[MESH]
  • |Choline/pharmacology[MESH]
  • |Magnesium/*pharmacology[MESH]
  • |Mannitol/pharmacology[MESH]
  • |Muscle Contraction/*drug effects[MESH]
  • |Muscle, Smooth, Vascular/drug effects/*physiology[MESH]
  • |Osmolar Concentration[MESH]
  • |Potassium Chloride/pharmacology[MESH]
  • |Rats[MESH]
  • |Rats, Inbred Strains[MESH]
  • |Sodium/*metabolism/pharmacology[MESH]
  • |Sucrose/pharmacology[MESH]
  • |Urea/pharmacology[MESH]


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