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10.1038/ki.2010.434

http://scihub22266oqcxt.onion/10.1038/ki.2010.434
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21228800!3621768!21228800
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suck abstract from ncbi

pmid21228800      Kidney+Int 2011 ; 79 (3): 269-71
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  • Angiotensin II: breathtaking in the renal medulla #MMPMID21228800
  • Haase VH
  • Kidney Int 2011[Feb]; 79 (3): 269-71 PMID21228800show ga
  • Angiotensin II (Ang II) is a major contributor to the progression of renal fibrosis. Wang and colleagues provide evidence that signaling through the prolyl-4-hydroxylase domain (PHD)-hypoxia-inducible factor-1 (HIF-1) pathway mediates profibrotic effects of Ang II in rat renal medullary interstitial cells under normoxic conditions, thus placing the HIF oxygen-sensing pathway into the center of an Ang II-induced profibrotic signaling cascade.
  • |Actins/metabolism[MESH]
  • |Angiotensin II/administration & dosage/*metabolism[MESH]
  • |Animals[MESH]
  • |Basic Helix-Loop-Helix Transcription Factors/genetics/metabolism[MESH]
  • |Cell Transdifferentiation[MESH]
  • |Collagen Type I/metabolism[MESH]
  • |Collagen Type III/metabolism[MESH]
  • |Fibrosis[MESH]
  • |Humans[MESH]
  • |Hydrogen Peroxide/metabolism[MESH]
  • |Hypoxia-Inducible Factor 1, alpha Subunit/genetics/*metabolism[MESH]
  • |Kidney Medulla/*metabolism/pathology[MESH]
  • |Procollagen-Proline Dioxygenase/genetics/metabolism[MESH]
  • |Proliferating Cell Nuclear Antigen/metabolism[MESH]
  • |Rats[MESH]
  • |Tissue Inhibitor of Metalloproteinase-1/metabolism[MESH]
  • |Up-Regulation[MESH]


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