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10.1007/s00701-010-0905-1

http://scihub22266oqcxt.onion/10.1007/s00701-010-0905-1
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21170556!ä!21170556

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suck abstract from ncbi


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pmid21170556      Acta+Neurochir+(Wien) 2011 ; 153 (3): 647-51
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  • Reduction in external ventricular drain infection rate Impact of a minimal handling protocol and antibiotic-impregnated catheters #MMPMID21170556
  • Rivero-Garvia M; Marquez-Rivas J; Jimenez-Mejias ME; Neth O; Rueda-Torres AB
  • Acta Neurochir (Wien) 2011[Mar]; 153 (3): 647-51 PMID21170556show ga
  • INTRODUCTION: Many strategies have been developed with the aim of reducing external ventricular drain-related infections. Antibiotic-impregnated catheters are one of them. MATERIAL AND METHODS: We report 648 cases of external ventricular drain from a total of 534 patients treated at the Virgen del Rocio Hospital between 1995 and 2006. Three subgroups were considered: group 1 included patients treated between 1995 and 2000, as well as a total of 190 external ventricular drains and 59 cases of infection (31.05%); group 2, with patients treated between 2000 and 2004 and managed with a minimal handling protocol, included 210 external ventricular drains and nine cases of infection (4.29%); and group 3, treated between 2004 and 2006, with 248 external ventricular drains and six cases of infection (2.41%). This latter subgroup included patients managed with a minimal handling protocol and antibiotic-impregnated catheters. RESULTS: Infection rate was 17% when non-antibiotic-impregnated catheters were employed and 2.41% when antibiotic-impregnated catheters were inserted (p < 0.001). This difference was statistically significant before and after the introduction of a minimal handling protocol, with percentages of 5.31% and 3.27%, respectively (p < 0.001; odds ratio 0.08; absolute risk reduction 27.26%). However, no statistically significant difference was observed in infection rate when the impact of a minimal handling protocol was considered: 4.29% when only the protocol was introduced and 2.41% when both the protocol and antibiotic-impregnated catheters were used (p > 0.05). CONCLUSION: Minimal handling protocols constitute an essential strategy in the reduction of external ventricular drain-related infections. Besides that, the use of antibiotic-impregnated catheters may reduce infection-related hospital costs.
  • |*Antibiotic Prophylaxis[MESH]
  • |*Coated Materials, Biocompatible[MESH]
  • |*Staphylococcus aureus[MESH]
  • |*Staphylococcus epidermidis[MESH]
  • |Anti-Bacterial Agents/*administration & dosage[MESH]
  • |Catheters, Indwelling/*microbiology[MESH]
  • |Cerebrospinal Fluid Shunts/*instrumentation[MESH]
  • |Cerebrospinal Fluid/microbiology[MESH]
  • |Clindamycin/*administration & dosage[MESH]
  • |Cross Infection/*prevention & control[MESH]
  • |Equipment Contamination/*prevention & control[MESH]
  • |Humans[MESH]
  • |Rifampin/*administration & dosage[MESH]
  • |Staphylococcal Infections/*prevention & control[MESH]
  • |Surgical Wound Infection/*prevention & control[MESH]


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