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10.1111/j.1530-0277.2010.01361.x http://scihub22266oqcxt.onion/10.1111/j.1530-0277.2010.01361.x 21158875/?report=reader!3476462!21158875     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=21158875&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Alcohol+Clin+Exp+Res 2011 ; 35 (3): 443-53 Nephropedia Template TP {{tp|p=21158875|t=2011. Amphetamine self-administration in light and moderate drinkers |pdf=|usr=}}{{21158875}} gab.com Text Amphetamine self-administration in light and moderate drinkers JO: Alcohol Clin Exp Res http://www.kidney.de/pget.php?&tw=1&pmid=21158875 #FOAvip BACKGROUND: Light and moderate drinkers respond differently to the effects of abused drugs, including stimulants such as amphetamine. The purpose of this study was to determine whether light and moderate drinkers differ in their sensitivity to the reinforcing and subjective effects of d-amphetamine. We hypothesized that moderate drinkers (i.e., participants that reported consuming at least seven alcohol-containing beverages per week) would be more sensitive to the reinforcing and positive subject-rated effects of d-amphetamine than light drinkers. METHODS: Data from four studies that employed similar d-amphetamine self-administration procedures and subject-rated drug-effect measures were included in the analysis. Light (n = 17) and moderate (n = 16) drinkers sampled placebo, low (8 to 10 mg), and high (16 to 20 mg) doses of oral d-amphetamine administered in eight capsules. Following sampling sessions, participants worked for a maximum of eight capsules, each containing 12.5% of the previously sampled dose, on a modified progressive-ratio schedule of reinforcement. RESULTS: Both active doses of d-amphetamine functioned as a reinforcer in the moderate drinkers, while only the high dose did so in the light drinkers. The moderate drinkers worked for significantly more capsules that contained the high dose of d-amphetamine than did the light drinkers. d-Amphetamine produced prototypical stimulant-like subjective effects (e.g., dose-dependent increases in ratings of Good Effects; Like Drug and Willing to Take Again). Moderate drinkers reported significantly greater subjective effects than the light drinkers. CONCLUSION: These results are consistent with those from previous laboratory experiments and suggest that moderate alcohol consumption may increase vulnerability to the abuse-related effects of stimulants. Twit Text FOAVip Amphetamine self-administration in light and moderate drinkers ????Alcohol Clin Exp Res http://www.kidney.de/pget.php?&tw=1&pmid=21158875 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21158875 #FOAvip English Wikipedia <ref>{{Cite pmid|21158875}}</ref> Amphetamine self-administration in light and moderate drinkers #MMPMID21158875 Stanley MD; Poole MM; Stoops WW; Rush CR Alcohol Clin Exp Res 2011[Mar]; 35 (3): 443-53 PMID21158875show ga BACKGROUND: Light and moderate drinkers respond differently to the effects of abused drugs, including stimulants such as amphetamine. The purpose of this study was to determine whether light and moderate drinkers differ in their sensitivity to the reinforcing and subjective effects of d-amphetamine. We hypothesized that moderate drinkers (i.e., participants that reported consuming at least seven alcohol-containing beverages per week) would be more sensitive to the reinforcing and positive subject-rated effects of d-amphetamine than light drinkers. METHODS: Data from four studies that employed similar d-amphetamine self-administration procedures and subject-rated drug-effect measures were included in the analysis. Light (n = 17) and moderate (n = 16) drinkers sampled placebo, low (8 to 10 mg), and high (16 to 20 mg) doses of oral d-amphetamine administered in eight capsules. Following sampling sessions, participants worked for a maximum of eight capsules, each containing 12.5% of the previously sampled dose, on a modified progressive-ratio schedule of reinforcement. RESULTS: Both active doses of d-amphetamine functioned as a reinforcer in the moderate drinkers, while only the high dose did so in the light drinkers. The moderate drinkers worked for significantly more capsules that contained the high dose of d-amphetamine than did the light drinkers. d-Amphetamine produced prototypical stimulant-like subjective effects (e.g., dose-dependent increases in ratings of Good Effects; Like Drug and Willing to Take Again). Moderate drinkers reported significantly greater subjective effects than the light drinkers. CONCLUSION: These results are consistent with those from previous laboratory experiments and suggest that moderate alcohol consumption may increase vulnerability to the abuse-related effects of stimulants. |*Reinforcement Schedule[MESH] |Adolescent[MESH] |Adult[MESH] |Alcohol Drinking/*psychology[MESH] |Amphetamine/*administration & dosage[MESH] |Behavior, Addictive/*psychology[MESH] |Dose-Response Relationship, Drug[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Self Administration[MESH] |Surveys and Questionnaires[MESH]Amphetamine self-administration in light and moderate drinkers (epmc).pdf DeepDyve Pubget Overpricing