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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Acta+Haematol 2011 ; 125 (3): 103-6 Nephropedia Template TP
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Plasma glial fibrillary acidic protein levels in a child with sickle cell disease and stroke #MMPMID21099215
Savage WJ; Everett AD; Casella JF
Acta Haematol 2011[]; 125 (3): 103-6 PMID21099215show ga
A 12-year-old boy with HbSS sickle cell disease (SCD) was admitted with an acute febrile illness and developed overt stroke 3 days later. Plasma glial fibrillary acidic protein levels were elevated, as compared to pediatric controls, 32 h prior to the clinical diagnosis of stroke, peaked immediately prior to the exchange transfusion, and remained elevated 1 year later despite chronic transfusion therapy. Stroke in SCD can occur in the setting of acute illness, and a biomarker that could predict the onset and triage ill children to therapeutic intervention more quickly would be useful.