Myeloid-derived suppressor cells in parasitic infections #MMPMID21061431
Van Ginderachter JA; Beschin A; De Baetselier P; Raes G
Eur J Immunol 2010[Nov]; 40 (11): 2976-85 PMID21061431show ga
Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells that share a common property of suppressing immune responses. Several helminth and protozoan parasite species have developed efficient strategies to increase the rate of medullary or extramedullary myelopoiesis and to induce the expansion and accumulation of immature myeloid cells such as MDSC. In this review, we examine current knowledge on the factors mediating enhanced myelopoiesis and MDSC induction and recruitment during parasitic infections and how the MDSC phenotype and mechanism of immune modulation and suppression depends on the factors they encounter within the host. Finally, we place MDSC expansion in the context of the critical balance between parasite elimination and pathogenicity to the host and suggest attractive avenues for future research.
Eur+J+Immunol 2010 ; 40 (11): 2976-85
