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10.1002/dvdy.22450 http://scihub22266oqcxt.onion/10.1002/dvdy.22450 21031419!10468760!21031419     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Dev+Dyn 2010 ; 239 (12): 3131-46 Nephropedia Template TP {{tp|p=21031419|t=2010. Far from solved: a perspective on what we know about early mechanisms of left-right asymmetry |pdf=|usr=}}{{21031419}} gab.com Text Far from solved: a perspective on what we know about early mechanisms of left-right asymmetry JO: Dev Dyn http://www.kidney.de/pget.php?&tw=1&pmid=21031419 #FOAvip Consistent laterality is a crucial aspect of embryonic development, physiology, and behavior. While strides have been made in understanding unilaterally expressed genes and the asymmetries of organogenesis, early mechanisms are still poorly understood. One popular model centers on the structure and function of motile cilia and subsequent chiral extracellular fluid flow during gastrulation. Alternative models focus on intracellular roles of the cytoskeleton in driving asymmetries of physiological signals or asymmetric chromatid segregation, at much earlier stages. All three models trace the origin of asymmetry back to the chirality of cytoskeletal organizing centers, but significant controversy exists about how this intracellular chirality is amplified onto cell fields. Analysis of specific predictions of each model and crucial recent data on new mutants suggest that ciliary function may not be a broadly conserved, initiating event in left-right patterning. Many questions about embryonic left-right asymmetry remain open, offering fascinating avenues for further research in cell, developmental, and evolutionary biology. Twit Text FOAVip Far from solved: a perspective on what we know about early mechanisms of left-right asymmetry ????Dev Dyn http://www.kidney.de/pget.php?&tw=1&pmid=21031419 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21031419 #FOAvip English Wikipedia <ref>{{Cite pmid|21031419}}</ref> Far from solved: a perspective on what we know about early mechanisms of left-right asymmetry #MMPMID21031419 Vandenberg LN; Levin M Dev Dyn 2010[Dec]; 239 (12): 3131-46 PMID21031419show ga Consistent laterality is a crucial aspect of embryonic development, physiology, and behavior. While strides have been made in understanding unilaterally expressed genes and the asymmetries of organogenesis, early mechanisms are still poorly understood. One popular model centers on the structure and function of motile cilia and subsequent chiral extracellular fluid flow during gastrulation. Alternative models focus on intracellular roles of the cytoskeleton in driving asymmetries of physiological signals or asymmetric chromatid segregation, at much earlier stages. All three models trace the origin of asymmetry back to the chirality of cytoskeletal organizing centers, but significant controversy exists about how this intracellular chirality is amplified onto cell fields. Analysis of specific predictions of each model and crucial recent data on new mutants suggest that ciliary function may not be a broadly conserved, initiating event in left-right patterning. Many questions about embryonic left-right asymmetry remain open, offering fascinating avenues for further research in cell, developmental, and evolutionary biology. |Animals[MESH] |Body Patterning/*physiology[MESH] |Embryonic Development[MESH] |Humans[MESH]Far from solved: a perspective on what we know about early mechanisms (epmc).pdf DeepDyve Pubget Overpricing