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10.1016/j.micinf.2010.10.004 http://scihub22266oqcxt.onion/10.1016/j.micinf.2010.10.004 20974275!ä!20974275 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Microbes+Infect 2011 ; 13 (2): 202-7 Nephropedia Template TP {{tp|p=20974275|t=2011. Correlation between sialic acid expression and infection of murine macrophages by different strains of influenza virus |pdf=|usr=}}{{20974275}} gab.com Text Correlation between sialic acid expression and infection of murine macrophages by different strains of influenza virus JO: Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=20974275 #FOAvip The mouse-adapted A/PR/8/34 (PR8; H1N1) virus infects airway macrophages poorly and is virulent in mice. Herein, we have investigated factors contributing to the ability of PR8 to evade murine macrophages. We demonstrate that the hemagglutinin of PR8 binds preferentially to alpha(2,3)-linked sialic acid (SA) and that murine macrophages express alpha(2,6)-linked SA. Moreover, resialylation of macrophages to express alpha(2,3)-linked SA restored susceptibility to PR8. Thus, during adaptation of human influenza viruses to growth in mice, a switch in receptor specificity from alpha(2,6)-linked SA to alpha(2,3)-linked SA is likely to favour evasion of attachment, entry and destruction by airway macrophages. Twit Text FOAVip Correlation between sialic acid expression and infection of murine macrophages by different strains of influenza virus ????Microbes Infect http://www.kidney.de/pget.php?&tw=1&pmid=20974275 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20974275 #FOAvip English Wikipedia <ref>{{Cite pmid|20974275}}</ref> Correlation between sialic acid expression and infection of murine macrophages by different strains of influenza virus #MMPMID20974275 Tate MD; Brooks AG; Reading PC Microbes Infect 2011[Feb]; 13 (2): 202-7 PMID20974275show ga The mouse-adapted A/PR/8/34 (PR8; H1N1) virus infects airway macrophages poorly and is virulent in mice. Herein, we have investigated factors contributing to the ability of PR8 to evade murine macrophages. We demonstrate that the hemagglutinin of PR8 binds preferentially to alpha(2,3)-linked sialic acid (SA) and that murine macrophages express alpha(2,6)-linked SA. Moreover, resialylation of macrophages to express alpha(2,3)-linked SA restored susceptibility to PR8. Thus, during adaptation of human influenza viruses to growth in mice, a switch in receptor specificity from alpha(2,6)-linked SA to alpha(2,3)-linked SA is likely to favour evasion of attachment, entry and destruction by airway macrophages. |*Hemagglutinin Glycoproteins, Influenza Virus/metabolism[MESH] |Animals[MESH] |Cell Line[MESH] |Dogs[MESH] |Epithelial Cells/virology[MESH] |Humans[MESH] |Influenza A Virus, H1N1 Subtype/*physiology[MESH] |Macrophages/*metabolism/*virology[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |N-Acetylneuraminic Acid/chemistry/*metabolism[MESH]Correlation between sialic acid expression and infection of murine mac(epmc).pdf DeepDyve Pubget Overpricing