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10.1002/cmdc.201000306 http://scihub22266oqcxt.onion/10.1002/cmdc.201000306 20967819!7162373!20967819     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ChemMedChem 2010 ; 5 (12): 2072-8 Nephropedia Template TP {{tp|p=20967819|t=2010. Polycyclic N-benzamido imides with potent activity against vaccinia virus |pdf=|usr=}}{{20967819}} gab.com Text Polycyclic N-benzamido imides with potent activity against vaccinia virus JO: ChemMedChem http://www.kidney.de/pget.php?&tw=1&pmid=20967819 #FOAvip The synthesis and antiviral activity of a series of novel polycyclic analogues of the orthopoxvirus egress inhibitor tecovirimat (ST-246) is presented. Several of these compounds display sub-micromolar activity against vaccinia virus, and were more potent than cidofovir (CDV). The more active compounds were about 10-fold more active than CDV, with minimum cytotoxic concentrations above 100 muM. Chemical manipulations of the two carbon-carbon double bonds present in the compounds were carried out to further explore the structure-activity relationships of these new polycyclic imides. Hydrogenation of the two carbon-carbon double bonds decreases antiviral activity, whereas either cyclopropanation or epoxidation of the double bonds fully eliminates the antiviral activity. Twit Text FOAVip Polycyclic N-benzamido imides with potent activity against vaccinia virus ????ChemMedChem http://www.kidney.de/pget.php?&tw=1&pmid=20967819 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20967819 #FOAvip English Wikipedia <ref>{{Cite pmid|20967819}}</ref> Polycyclic N-benzamido imides with potent activity against vaccinia virus #MMPMID20967819 Torres E; Duque MD; Camps P; Naesens L; Calvet T; Font-Bardia M; Vazquez S ChemMedChem 2010[Dec]; 5 (12): 2072-8 PMID20967819show ga The synthesis and antiviral activity of a series of novel polycyclic analogues of the orthopoxvirus egress inhibitor tecovirimat (ST-246) is presented. Several of these compounds display sub-micromolar activity against vaccinia virus, and were more potent than cidofovir (CDV). The more active compounds were about 10-fold more active than CDV, with minimum cytotoxic concentrations above 100 muM. Chemical manipulations of the two carbon-carbon double bonds present in the compounds were carried out to further explore the structure-activity relationships of these new polycyclic imides. Hydrogenation of the two carbon-carbon double bonds decreases antiviral activity, whereas either cyclopropanation or epoxidation of the double bonds fully eliminates the antiviral activity. |Antiviral Agents/chemical synthesis/*chemistry/pharmacology[MESH] |Benzamides/chemical synthesis/*chemistry/pharmacology[MESH] |Crystallography, X-Ray[MESH] |Drug Design[MESH] |Imides/chemical synthesis/*chemistry/pharmacology[MESH] |Isoindoles/chemical synthesis/chemistry/pharmacology[MESH] |Molecular Conformation[MESH] |Polycyclic Compounds/*chemistry[MESH] |Structure-Activity Relationship[MESH]Polycyclic N-benzamido imides with potent activity against vaccinia vi(epmc).pdf DeepDyve Pubget Overpricing