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10.1016/j.ejphar.2010.10.011 http://scihub22266oqcxt.onion/10.1016/j.ejphar.2010.10.011 20951695!ä!20951695 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Pharmacol 2011 ; 650 (1): 215-9 Nephropedia Template TP {{tp|p=20951695|t=2011. Clonidine inhibits itch-related response through stimulation of alpha(2)-adrenoceptors in the spinal cord in mice |pdf=|usr=}}{{20951695}} gab.com Text Clonidine inhibits itch-related response through stimulation of alpha(2)-adrenoceptors in the spinal cord in mice JO: Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=20951695 #FOAvip The present study investigated whether clonidine - an alpha(2)-adrenoceptor agonist known to relieve pain - is able to suppress itch-related behavior in mice. An intraplantar injection of serotonin induced biting (an itch-related response), which was inhibited by intraperitoneal and intrathecal, but not intraplantar or intracisternal, clonidine injections. The effect of intrathecal clonidine was inhibited by intrathecal injections of phentolamine (a non-selective alpha-adrenoceptor antagonist) and yohimbine (a selective alpha(2)-adrenoceptor antagonist), but not by prazosin (a selective alpha(1)-adrenoceptor antagonist). The effect of intraperitoneal clonidine was also inhibited by intrathecal yohimbine. These results suggest that clonidine is an effective antipruritic agent and that the effect is mainly mediated by the stimulation of alpha(2)-adrenoceptors in the dorsal horn. Twit Text FOAVip Clonidine inhibits itch-related response through stimulation of alpha(2)-adrenoceptors in the spinal cord in mice ????Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=20951695 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20951695 #FOAvip English Wikipedia <ref>{{Cite pmid|20951695}}</ref> Clonidine inhibits itch-related response through stimulation of alpha(2)-adrenoceptors in the spinal cord in mice #MMPMID20951695 Gotoh Y; Andoh T; Kuraishi Y Eur J Pharmacol 2011[Jan]; 650 (1): 215-9 PMID20951695show ga The present study investigated whether clonidine - an alpha(2)-adrenoceptor agonist known to relieve pain - is able to suppress itch-related behavior in mice. An intraplantar injection of serotonin induced biting (an itch-related response), which was inhibited by intraperitoneal and intrathecal, but not intraplantar or intracisternal, clonidine injections. The effect of intrathecal clonidine was inhibited by intrathecal injections of phentolamine (a non-selective alpha-adrenoceptor antagonist) and yohimbine (a selective alpha(2)-adrenoceptor antagonist), but not by prazosin (a selective alpha(1)-adrenoceptor antagonist). The effect of intraperitoneal clonidine was also inhibited by intrathecal yohimbine. These results suggest that clonidine is an effective antipruritic agent and that the effect is mainly mediated by the stimulation of alpha(2)-adrenoceptors in the dorsal horn. |Adrenergic alpha-2 Receptor Antagonists/pharmacology[MESH] |Animals[MESH] |Antipruritics/administration & dosage/*pharmacology/therapeutic use[MESH] |Behavior, Animal/drug effects[MESH] |Clonidine/administration & dosage/*pharmacology/therapeutic use[MESH] |Injections[MESH] |Male[MESH] |Mice[MESH] |Pruritus/chemically induced/*drug therapy/*metabolism[MESH] |Receptors, Adrenergic, alpha-2/*metabolism[MESH] |Serotonin/pharmacology[MESH]Clonidine inhibits itch-related response through stimulation of alpha(epmc).pdf DeepDyve Pubget Overpricing