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suck abstract from ncbi


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pmid2094063      Tokushima+J+Exp+Med 1990 ; 37 (3-4): 69-73
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  • Effect of magnesium sulfate on ventricular refractoriness and its efficacy for torsade de pointes #MMPMID2094063
  • Bando S; Yamamoto H; Nishikado A; Hamai K; Fujino K; Nakaya Y; Shinohara A
  • Tokushima J Exp Med 1990[Dec]; 37 (3-4): 69-73 PMID2094063show ga
  • The effect of magnesium sulfate on ventricular refractoriness and its efficacy for torsade de pointes (TdP) were studied in nineteen dogs. After the administration of quinidine sulfate (30 mg/kg), TdP was induced by ventricular pacing in ten of 19 dogs (52.6%), polymorphic ventricular tachycardia in seven (36.8%), ventricular fibrillation in two (10.5%). Quinidine sulfate caused significant increases in QTc interval, ventricular effective refractory period (ERP) and dispersion of ERP(dERP), and decrease in ERP/QT. Magnesium sulfate significantly increased ERP (p less than 0.01), but it did not change QT interval, resulting in significant increasing of ERP/QT (0.41 +/- 0.05 to 0.61 +/- 0.05, p less than 0.01). It decreased dERP but not significantly. Magnesium sulfate prevented the induction of TdP in eight of 10 dogs (80.0%) (30 mg/kg in four and 60 mg/kg in four). In conclusion, magnesium sulfate has value as first aid therapy for drug-induced TdP. If patients have ischemic heart disease or hypertension, we recommend infusion of magnesium for the initial therapy of TdP.
  • |Animals[MESH]
  • |Dogs[MESH]
  • |Drug Evaluation, Preclinical[MESH]
  • |Electric Stimulation[MESH]
  • |Heart Ventricles/drug effects[MESH]
  • |Magnesium Sulfate/*pharmacology[MESH]
  • |Quinidine/administration & dosage[MESH]
  • |Torsades de Pointes/*drug therapy/prevention & control[MESH]


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