Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1073/pnas.1009399107 http://scihub22266oqcxt.onion/10.1073/pnas.1009399107 20921420!2964195!20921420     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2010 ; 107 (42): 18010-5 Nephropedia Template TP {{tp|p=20921420|t=2010. Claudin-4 forms paracellular chloride channel in the kidney and requires claudin-8 for tight junction localization |pdf=|usr=}}{{20921420}} gab.com Text Claudin-4 forms paracellular chloride channel in the kidney and requires claudin-8 for tight junction localization JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=20921420 #FOAvip Tight junctions (TJs) play a key role in mediating paracellular ion reabsorption in the kidney. The paracellular pathway in the collecting duct of the kidney is a predominant route for transepithelial chloride reabsorption that determines the extracellular NaCl content and the blood pressure. However, the molecular mechanisms underlying the paracellular chloride reabsorption in the collecting duct are not understood. Here we showed that in mouse kidney collecting duct cells, claudin-4 functioned as a Cl(-) channel. A positively charged lysine residue at position 65 of claudin-4 was critical for its anion selectivity. Claudin-4 was observed to interact with claudin-8 using several criteria. In the collecting duct cells, the assembly of claudin-4 into TJ strands required its interaction with claudin-8. Depletion of claudin-8 resulted in the loss of paracellular chloride conductance, through a mechanism involving its recruitment of claudin-4 during TJ assembly. Together, our data show that claudin-4 interacts with claudin-8 and that their association is required for the anion-selective paracellular pathway in the collecting duct, suggesting a mechanism for coupling chloride reabsorption with sodium reabsorption in the collecting duct. Twit Text FOAVip Claudin-4 forms paracellular chloride channel in the kidney and requires claudin-8 for tight junction localization ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=20921420 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20921420 #FOAvip English Wikipedia <ref>{{Cite pmid|20921420}}</ref> Claudin-4 forms paracellular chloride channel in the kidney and requires claudin-8 for tight junction localization #MMPMID20921420 Hou J; Renigunta A; Yang J; Waldegger S Proc Natl Acad Sci U S A 2010[Oct]; 107 (42): 18010-5 PMID20921420show ga Tight junctions (TJs) play a key role in mediating paracellular ion reabsorption in the kidney. The paracellular pathway in the collecting duct of the kidney is a predominant route for transepithelial chloride reabsorption that determines the extracellular NaCl content and the blood pressure. However, the molecular mechanisms underlying the paracellular chloride reabsorption in the collecting duct are not understood. Here we showed that in mouse kidney collecting duct cells, claudin-4 functioned as a Cl(-) channel. A positively charged lysine residue at position 65 of claudin-4 was critical for its anion selectivity. Claudin-4 was observed to interact with claudin-8 using several criteria. In the collecting duct cells, the assembly of claudin-4 into TJ strands required its interaction with claudin-8. Depletion of claudin-8 resulted in the loss of paracellular chloride conductance, through a mechanism involving its recruitment of claudin-4 during TJ assembly. Together, our data show that claudin-4 interacts with claudin-8 and that their association is required for the anion-selective paracellular pathway in the collecting duct, suggesting a mechanism for coupling chloride reabsorption with sodium reabsorption in the collecting duct. |Amino Acid Sequence[MESH] |Animals[MESH] |Cell Membrane Permeability[MESH] |Chloride Channels/*metabolism[MESH] |Claudin-4[MESH] |Claudins[MESH] |Kidney Tubules, Collecting/*metabolism[MESH] |Membrane Proteins/chemistry/genetics/metabolism/*physiology[MESH] |Mice[MESH] |Molecular Sequence Data[MESH] |Mutagenesis[MESH] |Protein Binding[MESH] |RNA Interference[MESH] |Sequence Homology, Amino Acid[MESH]Claudin-4 forms paracellular chloride channel in the kidney and requir(epmc).pdf DeepDyve Pubget Overpricing