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10.1152/ajprenal.00153.2010 http://scihub22266oqcxt.onion/10.1152/ajprenal.00153.2010 20881034!3006314!20881034     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Renal+Physiol 2010 ; 299 (6): F1365-73 Nephropedia Template TP {{tp|p=20881034|t=2010. Renal protection in chronic kidney disease: hypoxia-inducible factor activation vs angiotensin II blockade |pdf=|usr=}}{{20881034}} gab.com Text Renal protection in chronic kidney disease: hypoxia-inducible factor activation vs angiotensin II blockade JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=20881034 #FOAvip The 5/6(th) nephrectomy or ablation/infarction (A/I) preparation has been used as a classic model of chronic kidney disease (CKD). We observed increased kidney oxygen consumption (Q(O2)) and altered renal hemodynamics in the A/I kidney that were normalized after combined angiotensin II (ANG II) blockade. Studies suggest hypoxia inducible factor as a protective influence in A/I. We induced hypoxia-inducible factor (HIF) and HIF target proteins by two different methods, cobalt chloride (CoCl(2)) and dimethyloxalyglycine (DMOG), for the first week after creation of A/I and compared the metabolic and renal hemodynamic outcomes to combined ANG II blockade. We also examined the HIF target proteins expressed by using Western blots and real-time PCR. Treatment with DMOG, CoCl(2), and ANG II blockade normalized kidney oxygen consumption factored by Na reabsorption and increased both renal blood flow and glomerular filtration rate. At 1 wk, CoCl(2) and DMOG increased kidney expression of HIF by Western blot. In the untreated A/I kidney, VEGF, heme oxygenase-1, and GLUT1 were all modestly increased. Both ANG II blockade and CoCl(2) therapy increased VEGF and GLUT1 but the cobalt markedly so. ANG II blockade decreased heme oxygenase-1 expression while CoCl(2) increased it. By real-time PCR, erythropoietin and GLUT1 were only increased by CoCl(2) therapy. Cell proliferation was modestly increased by ANG II blockade but markedly after cobalt therapy. Metabolic and hemodynamic abnormalities were corrected equally by ANG II blockade and HIF therapies. However, the molecular patterns differed significantly between ANG II blockade and cobalt therapy. HIF induction may prove to be protective in this model of CKD. Twit Text FOAVip Renal protection in chronic kidney disease: hypoxia-inducible factor activation vs angiotensin II blockade ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=20881034 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20881034 #FOAvip English Wikipedia <ref>{{Cite pmid|20881034}}</ref> Renal protection in chronic kidney disease: hypoxia-inducible factor activation vs angiotensin II blockade #MMPMID20881034 Deng A; Arndt MA; Satriano J; Singh P; Rieg T; Thomson S; Tang T; Blantz RC Am J Physiol Renal Physiol 2010[Dec]; 299 (6): F1365-73 PMID20881034show ga The 5/6(th) nephrectomy or ablation/infarction (A/I) preparation has been used as a classic model of chronic kidney disease (CKD). We observed increased kidney oxygen consumption (Q(O2)) and altered renal hemodynamics in the A/I kidney that were normalized after combined angiotensin II (ANG II) blockade. Studies suggest hypoxia inducible factor as a protective influence in A/I. We induced hypoxia-inducible factor (HIF) and HIF target proteins by two different methods, cobalt chloride (CoCl(2)) and dimethyloxalyglycine (DMOG), for the first week after creation of A/I and compared the metabolic and renal hemodynamic outcomes to combined ANG II blockade. We also examined the HIF target proteins expressed by using Western blots and real-time PCR. Treatment with DMOG, CoCl(2), and ANG II blockade normalized kidney oxygen consumption factored by Na reabsorption and increased both renal blood flow and glomerular filtration rate. At 1 wk, CoCl(2) and DMOG increased kidney expression of HIF by Western blot. In the untreated A/I kidney, VEGF, heme oxygenase-1, and GLUT1 were all modestly increased. Both ANG II blockade and CoCl(2) therapy increased VEGF and GLUT1 but the cobalt markedly so. ANG II blockade decreased heme oxygenase-1 expression while CoCl(2) increased it. By real-time PCR, erythropoietin and GLUT1 were only increased by CoCl(2) therapy. Cell proliferation was modestly increased by ANG II blockade but markedly after cobalt therapy. Metabolic and hemodynamic abnormalities were corrected equally by ANG II blockade and HIF therapies. However, the molecular patterns differed significantly between ANG II blockade and cobalt therapy. HIF induction may prove to be protective in this model of CKD. |Amino Acids, Dicarboxylic/pharmacology[MESH] |Angiotensin II/*antagonists & inhibitors[MESH] |Animals[MESH] |Carbonic Anhydrase IX[MESH] |Carbonic Anhydrases/metabolism[MESH] |Cobalt/pharmacology[MESH] |Enzyme Induction[MESH] |Glucose Transporter Type 1/biosynthesis[MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism[MESH] |Kidney Failure, Chronic/*metabolism[MESH] |Kidney/*drug effects[MESH] |Male[MESH] |Proliferating Cell Nuclear Antigen/metabolism[MESH] |Rats[MESH]Renal protection in chronic kidney disease: hypoxia-inducible factor a(epmc).pdf DeepDyve Pubget Overpricing