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10.1208/s12248-010-9220-2 http://scihub22266oqcxt.onion/10.1208/s12248-010-9220-2 20652780ApplicationofQuantitativePharmacologyinDevelopmentofTherapeuticMonoclonalAntibodies.!2977000!20652780     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       AAPS+J 2010 ; 12 (4): 592-601 Nephropedia Template TP {{tp|p=20652780|t=2010. Application of quantitative pharmacology in development of therapeutic monoclonal antibodies |pdf=|usr=}}{{20652780}} gab.com Text Application of quantitative pharmacology in development of therapeutic monoclonal antibodies JO: AAPS J http://www.kidney.de/pget.php?&tw=1&pmid=20652780 #FOAvip The advancement of therapeutic monoclonal antibodies during various stages of the drug development process can be effectively streamlined when appropriate translational strategies are applied. Design of successful translational strategies for development of monoclonal antibodies should allow for understanding of the dose- and concentration-response relationships with respect to both beneficial and toxic effects from early phases of drug development. Evaluation of relevant biomarkers during early stages of drug development should facilitate the successful design of safe and effective dosing strategies. Moreover, application of quantitative pharmacology is critical for translation of exposure-response relationships early on. Twit Text FOAVip Application of quantitative pharmacology in development of therapeutic monoclonal antibodies ????AAPS J http://www.kidney.de/pget.php?&tw=1&pmid=20652780 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20652780 #FOAvip English Wikipedia <ref>{{Cite pmid|20652780}}</ref> Application of quantitative pharmacology in development of therapeutic monoclonal antibodies #MMPMID20652780 Tabrizi M; Funelas C; Suria H AAPS J 2010[Dec]; 12 (4): 592-601 PMID20652780show ga The advancement of therapeutic monoclonal antibodies during various stages of the drug development process can be effectively streamlined when appropriate translational strategies are applied. Design of successful translational strategies for development of monoclonal antibodies should allow for understanding of the dose- and concentration-response relationships with respect to both beneficial and toxic effects from early phases of drug development. Evaluation of relevant biomarkers during early stages of drug development should facilitate the successful design of safe and effective dosing strategies. Moreover, application of quantitative pharmacology is critical for translation of exposure-response relationships early on. |Antibodies, Monoclonal/pharmacokinetics/*pharmacology/therapeutic use[MESH] |Humans[MESH]Application of quantitative pharmacology in development of therapeutic(epmc).pdf DeepDyve Pubget Overpricing