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10.1002/rmv.657 http://scihub22266oqcxt.onion/10.1002/rmv.657 20629046!7169116!20629046     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Rev+Med+Virol 2010 ; 20 (5): 298-310 Nephropedia Template TP {{tp|p=20629046|t=2010. Novel insights into proteolytic cleavage of influenza virus hemagglutinin |pdf=|usr=}}{{20629046}} gab.com Text Novel insights into proteolytic cleavage of influenza virus hemagglutinin JO: Rev Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=20629046 #FOAvip The influenza virus hemagglutinin (HA) mediates the first essential step in the viral life cycle, virus entry into target cells. Influenza virus HA is synthesised as a precursor protein in infected cells and requires cleavage by host cell proteases to transit into an active form. Cleavage is essential for influenza virus infectivity and the HA-processing proteases are attractive targets for therapeutic intervention. It is well established that cleavage by ubiquitously expressed subtilisin-like proteases is a hallmark of highly pathogenic avian influenza viruses (HPAIV). In contrast, the nature of the proteases responsible for cleavage of HA of human influenza viruses and low pathogenic avian influenza viruses (LPAIV) is not well understood. Recent studies suggest that cleavage of HA of human influenza viruses might be a cell-associated event and might be facilitated by the type II transmembrane serine proteases (TTSPs) TMPRSS2, TMPRSS4 and human airway trypsin-like protease (HAT). Here, we will introduce the different concepts established for proteolytic activation of influenza virus HA, with a particular focus on the role of TTSPs, and we will discuss their implications for viral tropism, pathogenicity and antiviral intervention. Twit Text FOAVip Novel insights into proteolytic cleavage of influenza virus hemagglutinin ????Rev Med Virol http://www.kidney.de/pget.php?&tw=1&pmid=20629046 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20629046 #FOAvip English Wikipedia <ref>{{Cite pmid|20629046}}</ref> Novel insights into proteolytic cleavage of influenza virus hemagglutinin #MMPMID20629046 Bertram S; Glowacka I; Steffen I; Kuhl A; Pohlmann S Rev Med Virol 2010[Sep]; 20 (5): 298-310 PMID20629046show ga The influenza virus hemagglutinin (HA) mediates the first essential step in the viral life cycle, virus entry into target cells. Influenza virus HA is synthesised as a precursor protein in infected cells and requires cleavage by host cell proteases to transit into an active form. Cleavage is essential for influenza virus infectivity and the HA-processing proteases are attractive targets for therapeutic intervention. It is well established that cleavage by ubiquitously expressed subtilisin-like proteases is a hallmark of highly pathogenic avian influenza viruses (HPAIV). In contrast, the nature of the proteases responsible for cleavage of HA of human influenza viruses and low pathogenic avian influenza viruses (LPAIV) is not well understood. Recent studies suggest that cleavage of HA of human influenza viruses might be a cell-associated event and might be facilitated by the type II transmembrane serine proteases (TTSPs) TMPRSS2, TMPRSS4 and human airway trypsin-like protease (HAT). Here, we will introduce the different concepts established for proteolytic activation of influenza virus HA, with a particular focus on the role of TTSPs, and we will discuss their implications for viral tropism, pathogenicity and antiviral intervention. |*Protein Processing, Post-Translational[MESH] |*Virus Internalization[MESH] |Hemagglutinins, Viral/*metabolism[MESH] |Humans[MESH] |Orthomyxoviridae/*physiology[MESH]Novel insights into proteolytic cleavage of influenza virus hemaggluti(epmc).pdf DeepDyve Pubget Overpricing