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10.1016/j.intimp.2010.06.009 http://scihub22266oqcxt.onion/10.1016/j.intimp.2010.06.009 20601184!ä!20601184 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+Immunopharmacol 2010 ; 10 (9): 1086-90 Nephropedia Template TP {{tp|p=20601184|t=2010. The bacterial extract OM-85 BV protects mice against influenza and Salmonella infection |pdf=|usr=}}{{20601184}} gab.com Text The bacterial extract OM-85 BV protects mice against influenza and Salmonella infection JO: Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=20601184 #FOAvip The bacterial extract OM-85 BV has been shown to provide protection against recurrent respiratory infections. We here investigated its efficacy against viral and bacterial infections in murine models. We first evaluated the role of OM-85 BV protecting from an A/PR/8/34 (H1N1) influenza virus infection. In a group treated with 1.75 mg/mouse OM-85 BV all animals survived, compared to 70% in the untreated control group and a group treated with a lower dosage. In addition, the appearance of clinical signs was delayed, their intensity was decreased, and they disappeared faster; also a marked increase in the influenza hemagglutination inhibition antibody level was observed. Since bacterial infections often superimpose viral lung infections, we also investigated on the protection of mice from a Salmonella typhimurium infection after the oral administration of OM-85 BV. Here, 100% of the OM-85 BV treated animals survived compared to 58% of the untreated control group. The mechanism of protection was further investigated: OM-85 BV acts, on the one hand, as an immunogen: the repeated administration of OM-85 BV induced a marked increase in serum antibody levels recognizing pathogenic bacterial strains. On the other hand, the extract acts as a stimulator of the nonspecific macrophage, monocyte, dendritic cell, and granulocyte response. Our findings demonstrate the antimicrobial activity of OM-85 BV against infections, as also has been shown in clinical studies. Twit Text FOAVip The bacterial extract OM-85 BV protects mice against influenza and Salmonella infection ????Int Immunopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=20601184 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20601184 #FOAvip English Wikipedia <ref>{{Cite pmid|20601184}}</ref> The bacterial extract OM-85 BV protects mice against influenza and Salmonella infection #MMPMID20601184 Bessler WG; Vor dem Esche U; Masihi N Int Immunopharmacol 2010[Sep]; 10 (9): 1086-90 PMID20601184show ga The bacterial extract OM-85 BV has been shown to provide protection against recurrent respiratory infections. We here investigated its efficacy against viral and bacterial infections in murine models. We first evaluated the role of OM-85 BV protecting from an A/PR/8/34 (H1N1) influenza virus infection. In a group treated with 1.75 mg/mouse OM-85 BV all animals survived, compared to 70% in the untreated control group and a group treated with a lower dosage. In addition, the appearance of clinical signs was delayed, their intensity was decreased, and they disappeared faster; also a marked increase in the influenza hemagglutination inhibition antibody level was observed. Since bacterial infections often superimpose viral lung infections, we also investigated on the protection of mice from a Salmonella typhimurium infection after the oral administration of OM-85 BV. Here, 100% of the OM-85 BV treated animals survived compared to 58% of the untreated control group. The mechanism of protection was further investigated: OM-85 BV acts, on the one hand, as an immunogen: the repeated administration of OM-85 BV induced a marked increase in serum antibody levels recognizing pathogenic bacterial strains. On the other hand, the extract acts as a stimulator of the nonspecific macrophage, monocyte, dendritic cell, and granulocyte response. Our findings demonstrate the antimicrobial activity of OM-85 BV against infections, as also has been shown in clinical studies. |*Influenza A Virus, H1N1 Subtype[MESH] |Adjuvants, Immunologic/*therapeutic use[MESH] |Animals[MESH] |Antibodies, Viral/blood[MESH] |Arthritis, Infectious/blood[MESH] |Bacteria[MESH] |Cell Extracts/*therapeutic use[MESH] |Dendritic Cells/drug effects/immunology[MESH] |Disease Models, Animal[MESH] |Granulocytes/drug effects/immunology[MESH] |Humans[MESH] |Influenza, Human/*prevention & control[MESH] |Lung Diseases/*drug therapy/immunology/virology[MESH] |Macrophages/drug effects/immunology[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Mice, Inbred C57BL[MESH] |Monocytes/drug effects/immunology[MESH] |Salmonella Infections/*prevention & control[MESH]The bacterial extract OM-85 BV protects mice against influenza and Sal(epmc).pdf DeepDyve Pubget Overpricing