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10.1016/j.bbadis.2010.06.016 http://scihub22266oqcxt.onion/10.1016/j.bbadis.2010.06.016 20600865!ä!20600865 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochim+Biophys+Acta 2010 ; 1802 (11): 952-8 Nephropedia Template TP {{tp|p=20600865|t=2010. Magnesium deficiency promotes a pro-atherogenic phenotype in cultured human endothelial cells via activation of NFkB |pdf=|usr=}}{{20600865}} gab.com Text Magnesium deficiency promotes a pro-atherogenic phenotype in cultured human endothelial cells via activation of NFkB JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=20600865 #FOAvip Phenotypic modulation of endothelium to a dysfunctional state contributes to the pathogenesis of atherosclerosis, partly through the activation of the transcription factor NFkB. Several data indicate that magnesium deficiency caused by prolonged insufficient intake and/or defects in its homeostasis may be a missing link between diverse cardiovascular risk factors and atherosclerosis. Here we report that endothelial cells cultured in low magnesium rapidly activate NFkB, an event which is prevented by exposure to the anti-oxidant trolox. It is well known that NFkB activation correlates with marked alterations of the cytokine network. In the present study, we show that exposure of endothelial cells to low magnesium increases the secretion of RANTES, interleukin 8 and platelet derived growth factor BB, all important players in atherogenesis. Moreover, we describe the increased secretion of matrix metalloprotease-2 and -9 and of their inhibitor TIMP-2. Interestingly, by zymography we show that metalloprotease activity predominated over the inhibitory effect of TIMP-2. These results indicate that low magnesium promotes endothelial dysfunction by inducing pro-inflammatory and pro-atherogenic events. Twit Text FOAVip Magnesium deficiency promotes a pro-atherogenic phenotype in cultured human endothelial cells via activation of NFkB ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=20600865 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20600865 #FOAvip English Wikipedia <ref>{{Cite pmid|20600865}}</ref> Magnesium deficiency promotes a pro-atherogenic phenotype in cultured human endothelial cells via activation of NFkB #MMPMID20600865 Ferre S; Baldoli E; Leidi M; Maier JA Biochim Biophys Acta 2010[Nov]; 1802 (11): 952-8 PMID20600865show ga Phenotypic modulation of endothelium to a dysfunctional state contributes to the pathogenesis of atherosclerosis, partly through the activation of the transcription factor NFkB. Several data indicate that magnesium deficiency caused by prolonged insufficient intake and/or defects in its homeostasis may be a missing link between diverse cardiovascular risk factors and atherosclerosis. Here we report that endothelial cells cultured in low magnesium rapidly activate NFkB, an event which is prevented by exposure to the anti-oxidant trolox. It is well known that NFkB activation correlates with marked alterations of the cytokine network. In the present study, we show that exposure of endothelial cells to low magnesium increases the secretion of RANTES, interleukin 8 and platelet derived growth factor BB, all important players in atherogenesis. Moreover, we describe the increased secretion of matrix metalloprotease-2 and -9 and of their inhibitor TIMP-2. Interestingly, by zymography we show that metalloprotease activity predominated over the inhibitory effect of TIMP-2. These results indicate that low magnesium promotes endothelial dysfunction by inducing pro-inflammatory and pro-atherogenic events. |Atherosclerosis/etiology/metabolism/pathology[MESH] |Becaplermin[MESH] |Blotting, Western[MESH] |Cells, Cultured[MESH] |Chemokine CCL5/metabolism[MESH] |Cytokines/*metabolism[MESH] |Dose-Response Relationship, Drug[MESH] |Endothelial Cells/*drug effects/metabolism[MESH] |Enzyme-Linked Immunosorbent Assay[MESH] |Humans[MESH] |Interleukin-6/metabolism[MESH] |Interleukin-8/metabolism[MESH] |Magnesium Deficiency/complications[MESH] |Magnesium/metabolism/*pharmacology[MESH] |Matrix Metalloproteinase 2/metabolism[MESH] |Matrix Metalloproteinase 9/metabolism[MESH] |NF-kappa B/*metabolism[MESH] |Platelet-Derived Growth Factor/metabolism[MESH] |Proto-Oncogene Proteins c-sis[MESH] |Tissue Inhibitor of Metalloproteinase-2/metabolism[MESH] |Transforming Growth Factor beta1/metabolism[MESH]Magnesium deficiency promotes a pro-atherogenic phenotype in cultured (epmc).pdf DeepDyve Pubget Overpricing