Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1002/med.20216 http://scihub22266oqcxt.onion/10.1002/med.20216 20577974!7168447!20577974     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Med+Res+Rev 2012 ; 32 (2): 349-87 Nephropedia Template TP {{tp|p=20577974|t=2012. Potential of carbohydrate-binding agents as therapeutics against enveloped viruses |pdf=|usr=}}{{20577974}} gab.com Text Potential of carbohydrate-binding agents as therapeutics against enveloped viruses JO: Med Res Rev http://www.kidney.de/pget.php?&tw=1&pmid=20577974 #FOAvip Twenty-seven years after the discovery of HIV as the cause of AIDS more than 25 drugs directed against four different viral targets (i.e. reverse transcriptase, protease, integrase, envelope gp41) and one cellular target (i.e. CCR5 co-receptor) are available for treatment. However, the search for an efficient vaccine is still ongoing. One of the main problems is the presence of a continuously evolving dense carbohydrate shield, consisting of N-linked glycans that surrounds the virion and protects it against efficient recognition and persistent neutralization by the immune system. However, several lectins from the innate immune system specifically bind to these glycans in an attempt to process the virus antigens to provoke an immune response. Across a wide variety of different species in nature lectins can be found that can interact with the glycosylated envelope of HIV-1 and can block the infection of susceptible cells by the virus. In this review, we will give an overview of the lectins from non-mammalian origin that are endowed with antiviral properties and discuss the complex interactions between lectins of the innate immune system and HIV-1. Also, attention will be given to different carbohydrate-related modalities that can be exploited for antiviral chemotherapy. Twit Text FOAVip Potential of carbohydrate-binding agents as therapeutics against enveloped viruses ????Med Res Rev http://www.kidney.de/pget.php?&tw=1&pmid=20577974 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20577974 #FOAvip English Wikipedia <ref>{{Cite pmid|20577974}}</ref> Potential of carbohydrate-binding agents as therapeutics against enveloped viruses #MMPMID20577974 Francois KO; Balzarini J Med Res Rev 2012[Mar]; 32 (2): 349-87 PMID20577974show ga Twenty-seven years after the discovery of HIV as the cause of AIDS more than 25 drugs directed against four different viral targets (i.e. reverse transcriptase, protease, integrase, envelope gp41) and one cellular target (i.e. CCR5 co-receptor) are available for treatment. However, the search for an efficient vaccine is still ongoing. One of the main problems is the presence of a continuously evolving dense carbohydrate shield, consisting of N-linked glycans that surrounds the virion and protects it against efficient recognition and persistent neutralization by the immune system. However, several lectins from the innate immune system specifically bind to these glycans in an attempt to process the virus antigens to provoke an immune response. Across a wide variety of different species in nature lectins can be found that can interact with the glycosylated envelope of HIV-1 and can block the infection of susceptible cells by the virus. In this review, we will give an overview of the lectins from non-mammalian origin that are endowed with antiviral properties and discuss the complex interactions between lectins of the innate immune system and HIV-1. Also, attention will be given to different carbohydrate-related modalities that can be exploited for antiviral chemotherapy. |Antiviral Agents/*therapeutic use[MESH] |Bacterial Proteins/therapeutic use[MESH] |Carrier Proteins/therapeutic use[MESH] |HIV Infections/drug therapy/immunology[MESH] |HIV-1/immunology/metabolism[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Lectins/therapeutic use[MESH] |Receptors, Cell Surface/therapeutic use[MESH]Potential of carbohydrate-binding agents as therapeutics against envel(epmc).pdf DeepDyve Pubget Overpricing