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10.1016/j.antiviral.2010.05.011 http://scihub22266oqcxt.onion/10.1016/j.antiviral.2010.05.011 20561966!ä!20561966 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antiviral+Res 2010 ; 87 (2): 249-56 Nephropedia Template TP {{tp|p=20561966|t=2010. Modulation of miR-122 on persistently Borna disease virus infected human oligodendroglial cells |pdf=|usr=}}{{20561966}} gab.com Text Modulation of miR-122 on persistently Borna disease virus infected human oligodendroglial cells JO: Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=20561966 #FOAvip Using RNAhybrid software we found the predicted binding of complementary sequences between miR-122 and viral mRNAs, may be important for the antiviral effect of miR-122 on Borna disease virus (BDV). A moderate expression of miR-122 was identified in human oligodendroglial cells (OL), but with a much lower level of miR-122 in BDV persistent infection (OL/BDV) and cells transfected with BDV gene expression vectors. Over-expression of miR-122 and specific blocking experiments demonstrated that miR-122 was able to specifically inhibit BDV protein synthesis, viral gene replication and transcription, and induce the secretion/synthesis of interferon (IFN) in OL and OL/BDV cells. The abolishment of miR-122 by AMO-122 inhibited endogenous IFN induction by IFN-beta. These results indicate that miR-122 can exert direct antiviral function by inhibiting BDV translation and replication on one hand, while acting indirectly through IFN to increase the host innate immunity to modulate the virus-host interactions on the other hand. Twit Text FOAVip Modulation of miR-122 on persistently Borna disease virus infected human oligodendroglial cells ????Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=20561966 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20561966 #FOAvip English Wikipedia <ref>{{Cite pmid|20561966}}</ref> Modulation of miR-122 on persistently Borna disease virus infected human oligodendroglial cells #MMPMID20561966 Qian J; Zhai A; Kao W; Li Y; Song W; Fu Y; Chen X; Zhang Q; Wu J; Li H; Zhong Z; Ling H; Zhang F Antiviral Res 2010[Aug]; 87 (2): 249-56 PMID20561966show ga Using RNAhybrid software we found the predicted binding of complementary sequences between miR-122 and viral mRNAs, may be important for the antiviral effect of miR-122 on Borna disease virus (BDV). A moderate expression of miR-122 was identified in human oligodendroglial cells (OL), but with a much lower level of miR-122 in BDV persistent infection (OL/BDV) and cells transfected with BDV gene expression vectors. Over-expression of miR-122 and specific blocking experiments demonstrated that miR-122 was able to specifically inhibit BDV protein synthesis, viral gene replication and transcription, and induce the secretion/synthesis of interferon (IFN) in OL and OL/BDV cells. The abolishment of miR-122 by AMO-122 inhibited endogenous IFN induction by IFN-beta. These results indicate that miR-122 can exert direct antiviral function by inhibiting BDV translation and replication on one hand, while acting indirectly through IFN to increase the host innate immunity to modulate the virus-host interactions on the other hand. |Borna disease virus/*immunology/*isolation & purification[MESH] |Gene Expression Profiling[MESH] |Humans[MESH] |Interferons/metabolism[MESH] |MicroRNAs/*biosynthesis/*genetics/immunology[MESH] |Nucleic Acid Hybridization[MESH] |Oligodendroglia/*immunology/*virology[MESH]Modulation of miR-122 on persistently Borna disease virus infected hum(epmc).pdf DeepDyve Pubget Overpricing