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10.4155/fmc.10.179 http://scihub22266oqcxt.onion/10.4155/fmc.10.179 20543968!2883187!20543968     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20543968&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Future+Med+Chem 2010 ; 2 (5): 757-74 Nephropedia Template TP {{tp|p=20543968|t=2010. Small-molecule modulators of inward rectifier K+ channels: recent advances and future possibilities |pdf=|usr=}}{{20543968}} gab.com Text Small-molecule modulators of inward rectifier K+ channels: recent advances and future possibilities JO: Future Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=20543968 #FOAvip Inward rectifier potassium (Kir) channels have been postulated as therapeutic targets for several common disorders including hypertension, cardiac arrhythmias and pain. With few exceptions, however, the small-molecule pharmacology of this family is limited to nonselective cardiovascular and neurologic drugs with off-target activity toward inward rectifiers. Consequently, the actual therapeutic potential and 'drugability' of most Kir channels has not yet been determined experimentally. The purpose of this review is to provide a comprehensive summary of publicly disclosed Kir channel small-molecule modulators and highlight recent targeted drug-discovery efforts toward Kir1.1 and Kir2.1. The review concludes with a brief speculation on how the field of Kir channel pharmacology will develop over the coming years and a discussion of the increasingly important role academic laboratories will play in this progress. Twit Text FOAVip Small-molecule modulators of inward rectifier K+ channels: recent advances and future possibilities ????Future Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=20543968 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20543968 #FOAvip English Wikipedia <ref>{{Cite pmid|20543968}}</ref> Small-molecule modulators of inward rectifier K+ channels: recent advances and future possibilities #MMPMID20543968 Bhave G; Lonergan D; Chauder BA; Denton JS Future Med Chem 2010[May]; 2 (5): 757-74 PMID20543968show ga Inward rectifier potassium (Kir) channels have been postulated as therapeutic targets for several common disorders including hypertension, cardiac arrhythmias and pain. With few exceptions, however, the small-molecule pharmacology of this family is limited to nonselective cardiovascular and neurologic drugs with off-target activity toward inward rectifiers. Consequently, the actual therapeutic potential and 'drugability' of most Kir channels has not yet been determined experimentally. The purpose of this review is to provide a comprehensive summary of publicly disclosed Kir channel small-molecule modulators and highlight recent targeted drug-discovery efforts toward Kir1.1 and Kir2.1. The review concludes with a brief speculation on how the field of Kir channel pharmacology will develop over the coming years and a discussion of the increasingly important role academic laboratories will play in this progress. |Animals[MESH] |Drug Discovery/*methods/trends[MESH] |Humans[MESH] |Models, Molecular[MESH] |Potassium Channels, Inwardly Rectifying/*agonists/*antagonists & inhibitors/chemistry/metabolism[MESH]Small-molecule modulators of inward rectifier K+ channels: recent adva(epmc).pdf DeepDyve Pubget Overpricing