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10.1183/09031936.00182909

http://scihub22266oqcxt.onion/10.1183/09031936.00182909
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20530034!ä!20530034

suck abstract from ncbi


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pmid20530034      Eur+Respir+J 2010 ; 36 (4): 792-9
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  • Riociguat for chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension: a phase II study #MMPMID20530034
  • Ghofrani HA; Hoeper MM; Halank M; Meyer FJ; Staehler G; Behr J; Ewert R; Weimann G; Grimminger F
  • Eur Respir J 2010[Oct]; 36 (4): 792-9 PMID20530034show ga
  • We assessed the therapeutic potential of riociguat, a novel soluble guanylate cyclase stimulator, in adults with chronic thromboembolic pulmonary hypertension (CTEPH; n = 42) or pulmonary arterial hypertension (PAH; n = 33) in World Health Organization (WHO) functional class II/III. In this 12-week, multicentre, open-label, uncontrolled phase II study, patients received oral riociguat 1.0-2.5 mg t.i.d. titrated according to systemic systolic blood pressure (SBP). Primary end-points were safety and tolerability; pharmacodynamic changes were secondary end-points. Riociguat was generally well tolerated. Asymptomatic hypotension (SBP <90 mmHg) occurred in 11 patients, but blood pressure normalised without dose alteration in nine and after dose reduction in two. Median 6-min walking distance increased in patients with CTEPH (55.0 m from baseline (390 m); p<0.0001) and PAH (57.0 m from baseline (337 m); p<0.0001); patients in functional class II or III and bosentan pre-treated patients showed similar improvements. Pulmonary vascular resistance was significantly reduced by 215 dyn.s.cm(-5) from baseline (709 dyn.s.cm(-5); p<0.0001). 42 (56%) patients were considered to have experienced drug-related adverse events (AEs; 96% mild or moderate). Dyspepsia, headache and hypotension were the most frequent AEs. Study discontinuation because of AEs was 4%. These preliminary data show that riociguat has a favourable safety profile and improves exercise capacity, symptoms and pulmonary haemodynamics in CTEPH and PAH. Randomised controlled trials are underway.
  • |Administration, Oral[MESH]
  • |Aged[MESH]
  • |Antihypertensive Agents/*pharmacology/therapeutic use[MESH]
  • |Exercise[MESH]
  • |Female[MESH]
  • |Guanylate Cyclase/metabolism[MESH]
  • |Humans[MESH]
  • |Hypertension, Pulmonary/*drug therapy[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Prospective Studies[MESH]
  • |Pyrazoles/*pharmacology[MESH]
  • |Pyrimidines/*pharmacology[MESH]
  • |Thromboembolism/*drug therapy[MESH]


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