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10.1161/ATVBAHA.110.207316 http://scihub22266oqcxt.onion/10.1161/ATVBAHA.110.207316 20508205!2906705!20508205     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arterioscler+Thromb+Vasc+Biol 2010 ; 30 (8): 1634-41 Nephropedia Template TP {{tp|p=20508205|t=2010. Role of heme oxygenase-1 in human endothelial cells: lesson from the promoter allelic variants |pdf=|usr=}}{{20508205}} gab.com Text Role of heme oxygenase-1 in human endothelial cells: lesson from the promoter allelic variants JO: Arterioscler Thromb Vasc Biol http://www.kidney.de/pget.php?&tw=1&pmid=20508205 #FOAvip OBJECTIVE: Heme oxygenase-1 (HO-1) is an antioxidative, antiinflammatory, and cytoprotective enzyme that is induced in response to cellular stress. The HO-1 promoter contains a (GT)n microsatellite DNA, and the number of GT repeats can influence the occurrence of cardiovascular diseases. We elucidated the effect of this polymorphism on endothelial cells isolated from newborns of different genotypes. METHODS AND RESULTS: On the basis of HO-1 expression, we classified the HO-1 promoter alleles into 3 groups: short (S) (most active, GT < or = 23), medium (moderately active, GT=24 to 28), and long (least active, GT > or = 29). The presence of the S allele led to higher basal HO-1 expression and stronger induction in response to cobalt protoporphyrin, prostaglandin-J(2), hydrogen peroxide, and lipopolysaccharide. Cells carrying the S allele survived better under oxidative stress, a fact associated with the lower concentration of oxidized glutathione and more favorable oxidative status, as determined by measurement of the ratio of glutathione to oxidized glutathione. Moreover, they proliferated more efficiently in response to vascular endothelial growth factor A, although the vascular endothelial growth factor-induced migration and sprouting of capillaries were not influenced. Finally, the presence of the S allele was associated with lower production of some proinflammatory mediators, such as interleukin-1beta, interleukin-6, and soluble intercellular adhesion molecule-1. CONCLUSIONS: The (GT)n promoter polymorphism significantly modulates a cytoprotective, proangiogenic, and antiinflammatory function of HO-1 in human endothelium. Twit Text FOAVip Role of heme oxygenase-1 in human endothelial cells: lesson from the promoter allelic variants ????Arterioscler Thromb Vasc Biol http://www.kidney.de/pget.php?&tw=1&pmid=20508205 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20508205 #FOAvip English Wikipedia <ref>{{Cite pmid|20508205}}</ref> Role of heme oxygenase-1 in human endothelial cells: lesson from the promoter allelic variants #MMPMID20508205 Taha H; Skrzypek K; Guevara I; Nigisch A; Mustafa S; Grochot-Przeczek A; Ferdek P; Was H; Kotlinowski J; Kozakowska M; Balcerczyk A; Muchova L; Vitek L; Weigel G; Dulak J; Jozkowicz A Arterioscler Thromb Vasc Biol 2010[Aug]; 30 (8): 1634-41 PMID20508205show ga OBJECTIVE: Heme oxygenase-1 (HO-1) is an antioxidative, antiinflammatory, and cytoprotective enzyme that is induced in response to cellular stress. The HO-1 promoter contains a (GT)n microsatellite DNA, and the number of GT repeats can influence the occurrence of cardiovascular diseases. We elucidated the effect of this polymorphism on endothelial cells isolated from newborns of different genotypes. METHODS AND RESULTS: On the basis of HO-1 expression, we classified the HO-1 promoter alleles into 3 groups: short (S) (most active, GT < or = 23), medium (moderately active, GT=24 to 28), and long (least active, GT > or = 29). The presence of the S allele led to higher basal HO-1 expression and stronger induction in response to cobalt protoporphyrin, prostaglandin-J(2), hydrogen peroxide, and lipopolysaccharide. Cells carrying the S allele survived better under oxidative stress, a fact associated with the lower concentration of oxidized glutathione and more favorable oxidative status, as determined by measurement of the ratio of glutathione to oxidized glutathione. Moreover, they proliferated more efficiently in response to vascular endothelial growth factor A, although the vascular endothelial growth factor-induced migration and sprouting of capillaries were not influenced. Finally, the presence of the S allele was associated with lower production of some proinflammatory mediators, such as interleukin-1beta, interleukin-6, and soluble intercellular adhesion molecule-1. CONCLUSIONS: The (GT)n promoter polymorphism significantly modulates a cytoprotective, proangiogenic, and antiinflammatory function of HO-1 in human endothelium. |*Dinucleotide Repeats[MESH] |*Promoter Regions, Genetic[MESH] |Alleles[MESH] |Cell Proliferation[MESH] |Cell Survival[MESH] |Cells, Cultured[MESH] |Cytoprotection[MESH] |Endothelial Cells/*enzymology/immunology[MESH] |Enzyme Induction[MESH] |Genetic Variation[MESH] |Genotype[MESH] |Glutathione/metabolism[MESH] |Guanine[MESH] |Heme Oxygenase-1/biosynthesis/*genetics/metabolism[MESH] |Humans[MESH] |Infant, Newborn[MESH] |Inflammation Mediators/metabolism[MESH] |Neovascularization, Physiologic[MESH] |Oxidative Stress[MESH] |Phenotype[MESH] |RNA, Messenger/metabolism[MESH] |Thymine[MESH]Role of heme oxygenase-1 in human endothelial cells: lesson from the p(epmc).pdf DeepDyve Pubget Overpricing