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10.1096/fj.10-154765 http://scihub22266oqcxt.onion/10.1096/fj.10-154765 20466874!2923354!20466874     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FASEB+J 2010 ; 24 (9): 3438-50 Nephropedia Template TP {{tp|p=20466874|t=2010. Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule |pdf=|usr=}}{{20466874}} gab.com Text Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule JO: FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=20466874 #FOAvip Klotho has profound effects on phosphate metabolism, but the mechanisms of how Klotho affects phosphate homeostasis is unknown. We detected Klotho in the proximal tubule cell, brush border, and urinary lumen, where phosphate homeostasis resides. Increasing Klotho in the kidney and urine chronically by transgenic overexpression or acutely by intravenous infusion caused hypophosphatemia, phosphaturia from decreased proximal phosphate reabsorption, and decreased activity and protein of the principal renal phosphate transporter NaPi-2a. The phosphaturic effect was present in FGF23-null mice, indicating a direct action distinct from Klotho's known role as a coreceptor for FGF23. Direct inhibition of NaPi-2a by Klotho was confirmed in cultured cells and in cell-free membrane vesicles characterized by acute inhibition of transport activity followed by decreased cell surface protein. Transport inhibition can be mimicked by recombinant beta-glucuronidase and is associated with proteolytic degradation and reduced surface NaPi-2a. The inhibitory effect of Klotho on NaPi-2a was blocked by beta-glucuronidase inhibitor but not by protease inhibitor. Klotho is a novel phosphaturic substance that acts as an enzyme in the proximal tubule urinary lumen by modifying glycans, which cause decreased transporter activity, followed by proteolytic degradation and possibly internalization of NaPi-2a from the apical membrane. Twit Text FOAVip Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule ????FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=20466874 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20466874 #FOAvip English Wikipedia <ref>{{Cite pmid|20466874}}</ref> Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule #MMPMID20466874 Hu MC; Shi M; Zhang J; Pastor J; Nakatani T; Lanske B; Razzaque MS; Rosenblatt KP; Baum MG; Kuro-o M; Moe OW FASEB J 2010[Sep]; 24 (9): 3438-50 PMID20466874show ga Klotho has profound effects on phosphate metabolism, but the mechanisms of how Klotho affects phosphate homeostasis is unknown. We detected Klotho in the proximal tubule cell, brush border, and urinary lumen, where phosphate homeostasis resides. Increasing Klotho in the kidney and urine chronically by transgenic overexpression or acutely by intravenous infusion caused hypophosphatemia, phosphaturia from decreased proximal phosphate reabsorption, and decreased activity and protein of the principal renal phosphate transporter NaPi-2a. The phosphaturic effect was present in FGF23-null mice, indicating a direct action distinct from Klotho's known role as a coreceptor for FGF23. Direct inhibition of NaPi-2a by Klotho was confirmed in cultured cells and in cell-free membrane vesicles characterized by acute inhibition of transport activity followed by decreased cell surface protein. Transport inhibition can be mimicked by recombinant beta-glucuronidase and is associated with proteolytic degradation and reduced surface NaPi-2a. The inhibitory effect of Klotho on NaPi-2a was blocked by beta-glucuronidase inhibitor but not by protease inhibitor. Klotho is a novel phosphaturic substance that acts as an enzyme in the proximal tubule urinary lumen by modifying glycans, which cause decreased transporter activity, followed by proteolytic degradation and possibly internalization of NaPi-2a from the apical membrane. |Animals[MESH] |Cells, Cultured[MESH] |Fibroblast Growth Factor-23[MESH] |Glucuronidase/antagonists & inhibitors/genetics/*metabolism/pharmacology[MESH] |Glycoproteins/pharmacology[MESH] |Homeostasis/drug effects/genetics[MESH] |Hypophosphatemia, Familial/chemically induced[MESH] |Immunoblotting[MESH] |Immunohistochemistry[MESH] |Kidney Tubules/*enzymology[MESH] |Klotho Proteins[MESH] |Mice[MESH] |Mice, Transgenic[MESH] |Microscopy, Fluorescence[MESH] |Microscopy, Immunoelectron[MESH] |Microvilli/metabolism[MESH] |Phosphates/metabolism[MESH] |Protease Inhibitors/pharmacology[MESH] |Reverse Transcriptase Polymerase Chain Reaction[MESH]Klotho: a novel phosphaturic substance acting as an autocrine enzyme i(epmc).pdf DeepDyve Pubget Overpricing