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10.3109/08860221003728713

http://scihub22266oqcxt.onion/10.3109/08860221003728713
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20446792!ä!20446792

suck abstract from ncbi


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pmid20446792      Ren+Fail 2010 ; 32 (4): 506-9
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  • Parvovirus B19-induced multisystemic vasculitis and acute endocapillary proliferative glomerulonephritis in a child #MMPMID20446792
  • Sakalli H; Baskin E; Bayrakci US; Melek E; Cengiz N; Ozdemir BH
  • Ren Fail 2010[May]; 32 (4): 506-9 PMID20446792show ga
  • A 10-year-old girl was admitted with fever, cough, maculopapular rash, hemoptysis, dark-colored urine, edema, multiple lymphadenopathies, and hepatosplenomegaly. She developed acute glomerulonephritis during the course of these complex clinical features. Laboratory data showed hematuria, proteinuria, and hypocomplementemia. Serological tests showed positive human parvovirus B19 (HPVB19)-specific immunoglobin M (IgM) and HPVB19 DNA was detected in the patient's serum using polymerase chain reaction (PCR). Renal biopsy revealed acute endocapillary proliferative glomerulonephritis (AEPGN) with coarse granular C3 depositions in a "starry sky pattern," which is more peculiar to poststreptococcal glomerulonephritis. Electron microscopy showed subendothelial and small hump-shaped subepithelial electron-dense deposits in glomerular capillary walls. There was no evidence of either any mycobacterial, staphylococcal, or streptococcal infection, and the diagnosis of Goodpasture syndrome and connective tissue disorders was excluded during clinical and laboratory investigations. A diagnosis of HPVB19-induced pleuropneumonitis and glomerulonephritis was made. Through a literature search there was no documented pediatric case of AEPGN induced by HPVB19, and this case represents, to our knowledge, the first time that a direct relationship between parvovirus infection and AEPGN has been demonstrated in a child.
  • |Acute Disease[MESH]
  • |Child[MESH]
  • |Diagnosis, Differential[MESH]
  • |Female[MESH]
  • |Glomerulonephritis/diagnosis/*virology[MESH]
  • |Humans[MESH]
  • |Parvoviridae Infections/diagnosis/*virology[MESH]
  • |Parvovirus B19, Human/*isolation & purification[MESH]


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