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10.1681/ASN.2009070759

http://scihub22266oqcxt.onion/10.1681/ASN.2009070759
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20360309!4577295!20360309
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suck abstract from ncbi


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pmid20360309      J+Am+Soc+Nephrol 2010 ; 21 (7): 1093-6
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  • Macula densa sensing and signaling mechanisms of renin release #MMPMID20360309
  • Peti-Peterdi J; Harris RC
  • J Am Soc Nephrol 2010[Jul]; 21 (7): 1093-6 PMID20360309show ga
  • Macula densa cells in the distal nephron, according to the classic paradigm, are salt sensors that generate paracrine chemical signals in the juxtaglomerular apparatus to control vital kidney functions, including renal blood flow, glomerular filtration, and renin release. Renin is the rate-limiting step in the activation of the renin-angiotensin system, a key modulator of body fluid homeostasis. Here, we discuss recent advances in understanding macula densa sensing and suggest these cells, in addition to salt, also sense various chemical and metabolic signals in the tubular environment that directly trigger renin release.
  • |Animals[MESH]
  • |Glomerular Filtration Rate/physiology[MESH]
  • |Homeostasis/physiology[MESH]
  • |Humans[MESH]
  • |Juxtaglomerular Apparatus/blood supply/*physiology[MESH]
  • |Kidney Tubules, Distal/blood supply/*physiology[MESH]
  • |Mice[MESH]
  • |Mice, Knockout[MESH]
  • |Models, Animal[MESH]
  • |Nephrons/blood supply/*physiology[MESH]
  • |Regional Blood Flow/physiology[MESH]
  • |Renin-Angiotensin System/physiology[MESH]
  • |Renin/*metabolism[MESH]


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