Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1007/s00401-010-0679-9 http://scihub22266oqcxt.onion/10.1007/s00401-010-0679-9 20354705/?report=reader!3183823!20354705     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Neuropathol 2010 ; 119 (5): 523-41 Nephropedia Template TP {{tp|p=20354705|t=2010. Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer s disease |pdf=|usr=}}{{20354705}} gab.com Text Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer s disease JO: Acta Neuropathol http://www.kidney.de/pget.php?&tw=1&pmid=20354705 #FOAvip The aberrant accumulation of aggregated beta-amyloid peptides (Abeta) as plaques is a hallmark of Alzheimer's disease (AD) neuropathology and reduction of Abeta has become a leading direction of emerging experimental therapies for the disease. The mechanism(s) whereby Abeta is involved in the pathophysiology of the disease remain(s) poorly understood. Initially fibrils, and subsequently oligomers of extracellular Abeta have been viewed as the most important pathogenic form of Abeta in AD. More recently, the intraneuronal accumulation of Abeta has been described in the brain, although technical considerations and its relevance in AD have made this a controversial topic. Here, we review the emerging evidence linking intraneuronal Abeta accumulation to the development of synaptic pathology and plaques in AD, and discuss the implications of intraneuronal beta-amyloid for AD pathology, biology, diagnosis and therapy. Twit Text FOAVip Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer s disease ????Acta Neuropathol http://www.kidney.de/pget.php?&tw=1&pmid=20354705 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20354705 #FOAvip English Wikipedia <ref>{{Cite pmid|20354705}}</ref> Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer s disease #MMPMID20354705 Gouras GK; Tampellini D; Takahashi RH; Capetillo-Zarate E Acta Neuropathol 2010[May]; 119 (5): 523-41 PMID20354705show ga The aberrant accumulation of aggregated beta-amyloid peptides (Abeta) as plaques is a hallmark of Alzheimer's disease (AD) neuropathology and reduction of Abeta has become a leading direction of emerging experimental therapies for the disease. The mechanism(s) whereby Abeta is involved in the pathophysiology of the disease remain(s) poorly understood. Initially fibrils, and subsequently oligomers of extracellular Abeta have been viewed as the most important pathogenic form of Abeta in AD. More recently, the intraneuronal accumulation of Abeta has been described in the brain, although technical considerations and its relevance in AD have made this a controversial topic. Here, we review the emerging evidence linking intraneuronal Abeta accumulation to the development of synaptic pathology and plaques in AD, and discuss the implications of intraneuronal beta-amyloid for AD pathology, biology, diagnosis and therapy. |Alzheimer Disease/metabolism/*pathology[MESH] |Amyloid beta-Peptides/*metabolism[MESH] |Brain/metabolism/pathology[MESH] |Humans[MESH] |Neurons/metabolism/*pathology[MESH] |Synapses/metabolism/*pathology[MESH]Intraneuronal beta-amyloid accumulation and synapse pathology in Alzhe(epmc).pdf DeepDyve Pubget Overpricing