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10.1016/j.ajhg.2010.01.021 http://scihub22266oqcxt.onion/10.1016/j.ajhg.2010.01.021 20159108/?report=reader!2820186!20159108     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Hum+Genet 2010 ; 86 (2): 109-12 Nephropedia Template TP {{tp|p=20159108|t=2010. Mapping allele-specific DNA methylation: a new tool for maximizing information from GWAS |pdf=|usr=}}{{20159108}} gab.com Text Mapping allele-specific DNA methylation: a new tool for maximizing information from GWAS JO: Am J Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=20159108 #FOAvip In this issue of The Journal, an article by Schalkwyk et al.(1) shows the landscape of allele-specific DNA methylation (ASM) in the human genome. ASM has long been studied as a hallmark of imprinted genes, and a chromosome-wide version of this phenomenon occurs, in a random fashion, during X chromosome inactivation in female cells. But the type of ASM motivating the study by Schalkwyk et al. is different. They used a high-resolution, methylation-sensitive SNP array (MSNP) method for genome-wide profiling of ASM in total peripheral-blood leukocytes (PBL) and buccal cells from a series of monozygotic twin pairs. Their data bring a new level of detail to our knowledge of a newly recognized phenomenon-nonimprinted, sequence-dependent ASM. They document the widespread occurrence of this phenomenon among human genes and discuss its basic implications for gene regulation and genetic-epigenetic interactions. But this paper and recent work from other laboratories(2,3) raises the possibility of a more immediate and practical application for ASM mapping, namely to help extract maximum information from genome-wide association studies. Twit Text FOAVip Mapping allele-specific DNA methylation: a new tool for maximizing information from GWAS ????Am J Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=20159108 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20159108 #FOAvip English Wikipedia <ref>{{Cite pmid|20159108}}</ref> Mapping allele-specific DNA methylation: a new tool for maximizing information from GWAS #MMPMID20159108 Tycko B Am J Hum Genet 2010[Feb]; 86 (2): 109-12 PMID20159108show ga In this issue of The Journal, an article by Schalkwyk et al.(1) shows the landscape of allele-specific DNA methylation (ASM) in the human genome. ASM has long been studied as a hallmark of imprinted genes, and a chromosome-wide version of this phenomenon occurs, in a random fashion, during X chromosome inactivation in female cells. But the type of ASM motivating the study by Schalkwyk et al. is different. They used a high-resolution, methylation-sensitive SNP array (MSNP) method for genome-wide profiling of ASM in total peripheral-blood leukocytes (PBL) and buccal cells from a series of monozygotic twin pairs. Their data bring a new level of detail to our knowledge of a newly recognized phenomenon-nonimprinted, sequence-dependent ASM. They document the widespread occurrence of this phenomenon among human genes and discuss its basic implications for gene regulation and genetic-epigenetic interactions. But this paper and recent work from other laboratories(2,3) raises the possibility of a more immediate and practical application for ASM mapping, namely to help extract maximum information from genome-wide association studies. |*Alleles[MESH] |*Chromosome Mapping[MESH] |Animals[MESH] |Base Sequence[MESH] |DNA Methylation/*genetics[MESH] |Epigenesis, Genetic[MESH] |Genome-Wide Association Study/*methods[MESH] |Humans[MESH] |Mice[MESH]Mapping allele-specific DNA methylation: a new tool for maximizing inf(epmc).pdf DeepDyve Pubget Overpricing