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10.1016/j.pharmthera.2010.01.003 http://scihub22266oqcxt.onion/10.1016/j.pharmthera.2010.01.003 20153367!2854323!20153367     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=20153367&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Pharmacol+Ther 2010 ; 126 (2): 119-45 Nephropedia Template TP {{tp|p=20153367|t=2010. Effects of tempol and redox-cycling nitroxides in models of oxidative stress |pdf=|usr=}}{{20153367}} gab.com Text Effects of tempol and redox-cycling nitroxides in models of oxidative stress JO: Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=20153367 #FOAvip Tempol is a redox-cycling nitroxide that promotes the metabolism of many reactive oxygen species (ROS) and improves nitric oxide bioavailability. It has been studied extensively in animal models of oxidative stress. Tempol has been shown to preserve mitochondria against oxidative damage and improve tissue oxygenation. Tempol improved insulin responsiveness in models of diabetes mellitus and improved the dyslipidemia, reduced the weight gain and prevented diastolic dysfunction and heart failure in fat-fed models of the metabolic syndrome. Tempol protected many organs, including the heart and brain, from ischemia/reperfusion damage. Tempol prevented podocyte damage, glomerulosclerosis, proteinuria and progressive loss of renal function in models of salt and mineralocorticosteroid excess. It reduced brain or spinal cord damage after ischemia or trauma and exerted a spinal analgesic action. Tempol improved survival in several models of shock. It protected normal cells from radiation while maintaining radiation sensitivity of tumor cells. Its paradoxical pro-oxidant action in tumor cells accounted for a reduction in spontaneous tumor formation. Tempol was effective in some models of neurodegeneration. Thus, tempol has been effective in preventing several of the adverse consequences of oxidative stress and inflammation that underlie radiation damage and many of the diseases associated with aging. Indeed, tempol given from birth prolonged the life span of normal mice. However, presently tempol has been used only in human subjects as a topical agent to prevent radiation-induced alopecia. Twit Text FOAVip Effects of tempol and redox-cycling nitroxides in models of oxidative stress ????Pharmacol Ther http://www.kidney.de/pget.php?&tw=1&pmid=20153367 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20153367 #FOAvip English Wikipedia <ref>{{Cite pmid|20153367}}</ref> Effects of tempol and redox-cycling nitroxides in models of oxidative stress #MMPMID20153367 Wilcox CS Pharmacol Ther 2010[May]; 126 (2): 119-45 PMID20153367show ga Tempol is a redox-cycling nitroxide that promotes the metabolism of many reactive oxygen species (ROS) and improves nitric oxide bioavailability. It has been studied extensively in animal models of oxidative stress. Tempol has been shown to preserve mitochondria against oxidative damage and improve tissue oxygenation. Tempol improved insulin responsiveness in models of diabetes mellitus and improved the dyslipidemia, reduced the weight gain and prevented diastolic dysfunction and heart failure in fat-fed models of the metabolic syndrome. Tempol protected many organs, including the heart and brain, from ischemia/reperfusion damage. Tempol prevented podocyte damage, glomerulosclerosis, proteinuria and progressive loss of renal function in models of salt and mineralocorticosteroid excess. It reduced brain or spinal cord damage after ischemia or trauma and exerted a spinal analgesic action. Tempol improved survival in several models of shock. It protected normal cells from radiation while maintaining radiation sensitivity of tumor cells. Its paradoxical pro-oxidant action in tumor cells accounted for a reduction in spontaneous tumor formation. Tempol was effective in some models of neurodegeneration. Thus, tempol has been effective in preventing several of the adverse consequences of oxidative stress and inflammation that underlie radiation damage and many of the diseases associated with aging. Indeed, tempol given from birth prolonged the life span of normal mice. However, presently tempol has been used only in human subjects as a topical agent to prevent radiation-induced alopecia. |Animals[MESH] |Antioxidants/adverse effects/*pharmacology/therapeutic use[MESH] |Cyclic N-Oxides/adverse effects/*pharmacology/therapeutic use[MESH] |Disease Models, Animal[MESH] |Humans[MESH] |Nitrogen Oxides/*metabolism[MESH] |Oxidation-Reduction[MESH] |Oxidative Stress/*drug effects[MESH]Effects of tempol and redox-cycling nitroxides in models of oxidative (epmc).pdf DeepDyve Pubget Overpricing