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10.1111/j.1360-0443.2009.02858.x http://scihub22266oqcxt.onion/10.1111/j.1360-0443.2009.02858.x 20148783/?report=reader!2857551!20148783     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Addiction 2010 ; 105 (4): 727-31 Nephropedia Template TP {{tp|p=20148783|t=2010. Human sex differences in d-amphetamine self-administration |pdf=|usr=}}{{20148783}} gab.com Text Human sex differences in d-amphetamine self-administration JO: Addiction http://www.kidney.de/pget.php?&tw=1&pmid=20148783 #FOAvip Women and men may respond differently to the effects of stimulants such as amphetamine and cocaine. AIM: In order to assess potential sex differences in the reinforcing effects of d-amphetamine, a retrospective-analysis was conducted on data collected from three studies that employed similar d-amphetamine self-administration procedures and used identical subject-rated drug-effect measures. METHODS: Data from 10 women and 15 men were included in the analysis. In all studies, participants sampled placebo, low (8-10 mg) or high (16-20 mg) dose oral d-amphetamine. Following sampling sessions, participants worked for capsules containing one eighth of the previously sampled dose on a modified progressive-ratio schedule of reinforcement. We hypothesized that women and men would be differentially sensitive to the reinforcing effects of d-amphetamine. A two-way mixed-model analysis of variance (sex and dose) and planned comparisons were used in the statistical analyses. RESULTS: The low dose of d-amphetamine functioned as a reinforcer in women, but not men, whereas the high dose of d-amphetamine functioned as a reinforcer in men, but not women. Men self-administered significantly more capsules under the high dose condition than women. CONCLUSION: The results of this study suggest that men are more sensitive to the reinforcing effects of a high dose of d-amphetamine than women. Future research is needed that determines prospectively the reinforcing effects of weight-adjusted doses of d-amphetamine in women and men while controlling for menstrual cycle phase. Twit Text FOAVip Human sex differences in d-amphetamine self-administration ????Addiction http://www.kidney.de/pget.php?&tw=1&pmid=20148783 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20148783 #FOAvip English Wikipedia <ref>{{Cite pmid|20148783}}</ref> Human sex differences in d-amphetamine self-administration #MMPMID20148783 Vansickel AR; Stoops WW; Rush CR Addiction 2010[Apr]; 105 (4): 727-31 PMID20148783show ga Women and men may respond differently to the effects of stimulants such as amphetamine and cocaine. AIM: In order to assess potential sex differences in the reinforcing effects of d-amphetamine, a retrospective-analysis was conducted on data collected from three studies that employed similar d-amphetamine self-administration procedures and used identical subject-rated drug-effect measures. METHODS: Data from 10 women and 15 men were included in the analysis. In all studies, participants sampled placebo, low (8-10 mg) or high (16-20 mg) dose oral d-amphetamine. Following sampling sessions, participants worked for capsules containing one eighth of the previously sampled dose on a modified progressive-ratio schedule of reinforcement. We hypothesized that women and men would be differentially sensitive to the reinforcing effects of d-amphetamine. A two-way mixed-model analysis of variance (sex and dose) and planned comparisons were used in the statistical analyses. RESULTS: The low dose of d-amphetamine functioned as a reinforcer in women, but not men, whereas the high dose of d-amphetamine functioned as a reinforcer in men, but not women. Men self-administered significantly more capsules under the high dose condition than women. CONCLUSION: The results of this study suggest that men are more sensitive to the reinforcing effects of a high dose of d-amphetamine than women. Future research is needed that determines prospectively the reinforcing effects of weight-adjusted doses of d-amphetamine in women and men while controlling for menstrual cycle phase. |Adolescent[MESH] |Adult[MESH] |Analysis of Variance[MESH] |Behavior, Addictive/psychology[MESH] |Blood Pressure/drug effects[MESH] |Central Nervous System Stimulants/*administration & dosage/pharmacology[MESH] |Dextroamphetamine/*administration & dosage/pharmacology[MESH] |Dose-Response Relationship, Drug[MESH] |Drug Administration Schedule[MESH] |Female[MESH] |Heart Rate/drug effects[MESH] |Humans[MESH] |Male[MESH] |Menstrual Cycle[MESH] |Reinforcement Schedule[MESH] |Retrospective Studies[MESH] |Self Administration[MESH] |Sex Factors[MESH]Human sex differences in d-amphetamine self-administration (epmc).pdf DeepDyve Pubget Overpricing