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10.1016/j.bbagrm.2009.11.014 http://scihub22266oqcxt.onion/10.1016/j.bbagrm.2009.11.014 20123075/?report=reader!2818552!20123075     free     free     free       Biochim+Biophys+Acta 2010 ; 1799 (1-2): 131-40 Nephropedia Template TP {{tp|p=20123075|t=2010. High-mobility group box 1 and cancer |pdf=|usr=}}{{20123075}} gab.com Text High-mobility group box 1 and cancer JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=20123075 #FOAvip High-mobility group box 1 protein (HMGB1), a chromatin associated nuclear protein and extracellular damage associated molecular pattern molecule (DAMP), is an evolutionarily ancient and critical regulator of cell death and survival. Overexpression of HMGB1 is associated with each of the hallmarks of cancer including unlimited replicative potential, ability to develop blood vessels (angiogenesis), evasion of programmed cell death (apoptosis), self-sufficiency in growth signals, insensitivity to inhibitors of growth, inflammation, tissue invasion and metastasis. Our studies and those of our colleagues suggest that HMGB1 is central to cancer (abnormal wound healing) and many of the findings in normal wound healing as well. Here, we focus on the role of HMGB1 in cancer, the mechanisms by which it contributes to carcinogenesis, and therapeutic strategies based on targeting HMGB1. Twit Text FOAVip High-mobility group box 1 and cancer ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=20123075 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20123075 #FOAvip English Wikipedia <ref>{{Cite pmid|20123075}}</ref> High-mobility group box 1 and cancer #MMPMID20123075 Tang D; Kang R; Zeh HJ 3rd; Lotze MT Biochim Biophys Acta 2010[Jan]; 1799 (1-2): 131-40 PMID20123075show ga High-mobility group box 1 protein (HMGB1), a chromatin associated nuclear protein and extracellular damage associated molecular pattern molecule (DAMP), is an evolutionarily ancient and critical regulator of cell death and survival. Overexpression of HMGB1 is associated with each of the hallmarks of cancer including unlimited replicative potential, ability to develop blood vessels (angiogenesis), evasion of programmed cell death (apoptosis), self-sufficiency in growth signals, insensitivity to inhibitors of growth, inflammation, tissue invasion and metastasis. Our studies and those of our colleagues suggest that HMGB1 is central to cancer (abnormal wound healing) and many of the findings in normal wound healing as well. Here, we focus on the role of HMGB1 in cancer, the mechanisms by which it contributes to carcinogenesis, and therapeutic strategies based on targeting HMGB1. |Animals[MESH] |Cell Nucleus/metabolism[MESH] |HMGB1 Protein/chemistry/genetics/*metabolism[MESH] |Humans[MESH] |NF-kappa B/metabolism[MESH] |Neoplasms/blood supply/*metabolism/pathology/therapy[MESH] |Receptors, Estrogen/metabolism[MESH]High-mobility group box 1 and cancer (epmc).pdf DeepDyve Pubget Overpricing