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10.1002/iub.300 http://scihub22266oqcxt.onion/10.1002/iub.300 20073038!7165618!20073038     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       IUBMB+Life 2010 ; 62 (2): 140-57 Nephropedia Template TP {{tp|p=20073038|t=2010. Emerging roles of deubiquitinases in cancer-associated pathways |pdf=|usr=}}{{20073038}} gab.com Text Emerging roles of deubiquitinases in cancer-associated pathways JO: IUBMB Life http://www.kidney.de/pget.php?&tw=1&pmid=20073038 #FOAvip Deubiquitinases (DUBs) are emerging as important regulators of many pathways germane to cancer. They may regulate the stability of key oncogenes, exemplified by USP28 stabilisation of c-Myc. Alternatively they can negatively regulate ubiquitin-dependent signalling cascades such as the NF-kappaB activation pathway. We review the current literature that associates DUBs with cancer and discuss their suitability as drug targets of the future. Twit Text FOAVip Emerging roles of deubiquitinases in cancer-associated pathways ????IUBMB Life http://www.kidney.de/pget.php?&tw=1&pmid=20073038 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20073038 #FOAvip English Wikipedia <ref>{{Cite pmid|20073038}}</ref> Emerging roles of deubiquitinases in cancer-associated pathways #MMPMID20073038 Sacco JJ; Coulson JM; Clague MJ; Urbe S IUBMB Life 2010[Feb]; 62 (2): 140-57 PMID20073038show ga Deubiquitinases (DUBs) are emerging as important regulators of many pathways germane to cancer. They may regulate the stability of key oncogenes, exemplified by USP28 stabilisation of c-Myc. Alternatively they can negatively regulate ubiquitin-dependent signalling cascades such as the NF-kappaB activation pathway. We review the current literature that associates DUBs with cancer and discuss their suitability as drug targets of the future. |Animals[MESH] |Carboxypeptidases/physiology[MESH] |Carcinoma, Adenoid Cystic/physiopathology[MESH] |Cell Proliferation/drug effects[MESH] |Deubiquitinating Enzyme CYLD[MESH] |Endopeptidases/*physiology[MESH] |Fanconi Anemia/physiopathology[MESH] |Fatty Acid Synthases/physiology[MESH] |Forkhead Transcription Factors/physiology[MESH] |Genes, myc/physiology[MESH] |Humans[MESH] |Male[MESH] |NF-kappa B/physiology[MESH] |Neoplasms/metabolism/*physiopathology[MESH] |Oncogenes/*physiology[MESH] |PTEN Phosphohydrolase/physiology[MESH] |Peptide Hydrolases[MESH] |Prostatic Neoplasms/physiopathology[MESH] |Receptor Protein-Tyrosine Kinases/physiology[MESH] |Signal Transduction/*physiology[MESH] |Transforming Growth Factor beta/physiology[MESH] |Tumor Suppressor Protein p53/physiology[MESH] |Tumor Suppressor Proteins/physiology[MESH] |Ubiquitin Thiolesterase/*physiology[MESH] |Ubiquitin-Protein Ligases/*physiology[MESH] |Ubiquitin-Specific Peptidase 7[MESH] |Ubiquitin-Specific Proteases[MESH] |Ubiquitin/*metabolism[MESH]Emerging roles of deubiquitinases in cancer-associated pathways (epmc).pdf DeepDyve Pubget Overpricing