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10.4161/auto.6.1.10815 http://scihub22266oqcxt.onion/10.4161/auto.6.1.10815 20023429!ä!20023429 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 259.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Autophagy 2010 ; 6 (1): 182-3 Nephropedia Template TP {{tp|p=20023429|t=2010. Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation |pdf=|usr=}}{{20023429}} gab.com Text Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=20023429 #FOAvip Tau aggregation characterizes a series of neurodegenerative diseases including AD and other tauopathies. The distribution of Tau deposits correlates with the loss of neurons in these neurodegenerative diseases, and Tau-induced toxicity depends on its ability to aggregate. We have used an inducible cell model to study the expression of Tau variants, the buildup of aggregates, and their removal by the autophagy-lysosomal system. Incomplete chaperone-mediated autophagy of Tau generates amyloidogenic fragments that promote aggregation. The Tau aggregates are removed from cells by macroautophagy. Thus the two autophagic pathways could become possible therapeutic targets. Twit Text FOAVip Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=20023429 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20023429 #FOAvip English Wikipedia <ref>{{Cite pmid|20023429}}</ref> Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation #MMPMID20023429 Wang Y; Martinez-Vicente M; Kruger U; Kaushik S; Wong E; Mandelkow EM; Cuervo AM; Mandelkow E Autophagy 2010[Jan]; 6 (1): 182-3 PMID20023429show ga Tau aggregation characterizes a series of neurodegenerative diseases including AD and other tauopathies. The distribution of Tau deposits correlates with the loss of neurons in these neurodegenerative diseases, and Tau-induced toxicity depends on its ability to aggregate. We have used an inducible cell model to study the expression of Tau variants, the buildup of aggregates, and their removal by the autophagy-lysosomal system. Incomplete chaperone-mediated autophagy of Tau generates amyloidogenic fragments that promote aggregation. The Tau aggregates are removed from cells by macroautophagy. Thus the two autophagic pathways could become possible therapeutic targets. |Animals[MESH] |Autophagy/*physiology[MESH] |Cells/metabolism/*pathology[MESH] |Humans[MESH] |Models, Biological[MESH] |Molecular Chaperones/agonists/antagonists & inhibitors/metabolism/*physiology[MESH] |Plaque, Amyloid/metabolism/pathology[MESH] |Tauopathies/metabolism/*pathology[MESH]Synergy and antagonism of macroautophagy and chaperone-mediated autoph(epmc).pdf DeepDyve Pubget Overpricing