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10.4149/av_2009_04_233 http://scihub22266oqcxt.onion/10.4149/av_2009_04_233 19941386!ä!19941386 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Virol 2009 ; 53 (4): 233-40 Nephropedia Template TP {{tp|p=19941386|t=2009. Interleukin 12 is a primary cytokine responding to influenza virus infection in the respiratory tract of mice |pdf=|usr=}}{{19941386}} gab.com Text Interleukin 12 is a primary cytokine responding to influenza virus infection in the respiratory tract of mice JO: Acta Virol http://www.kidney.de/pget.php?&tw=1&pmid=19941386 #FOAvip We have reported previously that an increase in interleukin 12 (IL-12) production in the lungs of mice infected with Influenza A virus or an intranasal (i.n.) administration of IL-12 to the infected mice alleviated pneumonia (Tsurita et al., J. Pharmacol. Exp. Therapeut. 298, 362-368, 2001). In this study, we found that in the bronchoalveolar lavage fluids (BALF) obtained from mice infected i.n. with Influenza A virus IL-12 was elevated on day 1 post infection (p.i.) and was followed by tumor necrosis factor alfa (TNF-alfa), IL-18, and interferons alfa, beta, and gama (IFN-alfa, -beta, and -gama) on day 2 p.i. Histochemical analyses of the infected lungs on day 1 p.i. showed the presence of IL-12 and IL-12 mRNA in mononuclear and macrophage-like cells and co-localization of macrophages with viral antigen, while other cytokines were absent. Thus, IL-12 was produced by macrophages infiltrating the infected epithelium as the first response cytokine and its production at the site of infection may direct an early immune defense to alleviate the severity of infection. Twit Text FOAVip Interleukin 12 is a primary cytokine responding to influenza virus infection in the respiratory tract of mice ????Acta Virol http://www.kidney.de/pget.php?&tw=1&pmid=19941386 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19941386 #FOAvip English Wikipedia <ref>{{Cite pmid|19941386}}</ref> Interleukin 12 is a primary cytokine responding to influenza virus infection in the respiratory tract of mice #MMPMID19941386 Hama Y; Kurokawa M; Imakita M; Yoshida Y; Shimizu T; Watanabe W; Shiraki K Acta Virol 2009[]; 53 (4): 233-40 PMID19941386show ga We have reported previously that an increase in interleukin 12 (IL-12) production in the lungs of mice infected with Influenza A virus or an intranasal (i.n.) administration of IL-12 to the infected mice alleviated pneumonia (Tsurita et al., J. Pharmacol. Exp. Therapeut. 298, 362-368, 2001). In this study, we found that in the bronchoalveolar lavage fluids (BALF) obtained from mice infected i.n. with Influenza A virus IL-12 was elevated on day 1 post infection (p.i.) and was followed by tumor necrosis factor alfa (TNF-alfa), IL-18, and interferons alfa, beta, and gama (IFN-alfa, -beta, and -gama) on day 2 p.i. Histochemical analyses of the infected lungs on day 1 p.i. showed the presence of IL-12 and IL-12 mRNA in mononuclear and macrophage-like cells and co-localization of macrophages with viral antigen, while other cytokines were absent. Thus, IL-12 was produced by macrophages infiltrating the infected epithelium as the first response cytokine and its production at the site of infection may direct an early immune defense to alleviate the severity of infection. |Animals[MESH] |Bronchoalveolar Lavage Fluid/cytology/*immunology[MESH] |Cytokines/*immunology/metabolism[MESH] |Female[MESH] |Influenza A Virus, H1N1 Subtype/immunology/*pathogenicity[MESH] |Interleukin-12/immunology/*metabolism[MESH] |Leukocytes, Mononuclear/immunology[MESH] |Lung/cytology/*immunology[MESH] |Macrophages/immunology/metabolism[MESH] |Mice[MESH] |Mice, Inbred DBA[MESH] |Orthomyxoviridae Infections/*immunology/virology[MESH] |Pneumonia, Viral/immunology/virology[MESH]Interleukin 12 is a primary cytokine responding to influenza virus inf(epmc).pdf DeepDyve Pubget Overpricing