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10.4149/av_2009_04_225 http://scihub22266oqcxt.onion/10.4149/av_2009_04_225 19941385!ä!19941385 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Virol 2009 ; 53 (4): 225-31 Nephropedia Template TP {{tp|p=19941385|t=2009. Role of macrophage migration inhibitory factor in influenza H5N1 virus pneumonia |pdf=|usr=}}{{19941385}} gab.com Text Role of macrophage migration inhibitory factor in influenza H5N1 virus pneumonia JO: Acta Virol http://www.kidney.de/pget.php?&tw=1&pmid=19941385 #FOAvip The severe and often fatal disease in humans and birds caused by H5N1 influenza viruses has been attributed to aberrant pulmonary inflammatory responses. We investigated the role of macrophage migration inhibitory factor (MIF), a proinflammatory cytokine and a pivotal regulator of innate immunity, in H5N1 influenza virus pneumonia in murine model. We found increased MIF mRNA levels in the lungs and MIF protein levels in the serum of infected mice. Although the inhibition of MIF action by isoxazolone-1 (ISO-1) did not render mice more resistant to the lethality of infection, it caused a significant reduction in pulmonary inflammatory cytokines interleukin-1 beta (IL-1beta), IL-6 and tumor necrosis factor alpha (TNF-alphalfa) and chemokine interferon-inducible protein-10 (IP-10). These results indicate the involvement of MIF in inflammatory responses to H5N1 influenza virus infections by induction of pulmonary inflammatory cytokines and chemokines, and suggest that pharmacotherapeutic approaches targeting MIF may hold promise for the treatment of H5N1 influenza virus pneumonia. Twit Text FOAVip Role of macrophage migration inhibitory factor in influenza H5N1 virus pneumonia ????Acta Virol http://www.kidney.de/pget.php?&tw=1&pmid=19941385 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19941385 #FOAvip English Wikipedia <ref>{{Cite pmid|19941385}}</ref> Role of macrophage migration inhibitory factor in influenza H5N1 virus pneumonia #MMPMID19941385 Hou XQ; Gao YW; Yang ST; Wang CY; Ma ZY; Xia XZ Acta Virol 2009[]; 53 (4): 225-31 PMID19941385show ga The severe and often fatal disease in humans and birds caused by H5N1 influenza viruses has been attributed to aberrant pulmonary inflammatory responses. We investigated the role of macrophage migration inhibitory factor (MIF), a proinflammatory cytokine and a pivotal regulator of innate immunity, in H5N1 influenza virus pneumonia in murine model. We found increased MIF mRNA levels in the lungs and MIF protein levels in the serum of infected mice. Although the inhibition of MIF action by isoxazolone-1 (ISO-1) did not render mice more resistant to the lethality of infection, it caused a significant reduction in pulmonary inflammatory cytokines interleukin-1 beta (IL-1beta), IL-6 and tumor necrosis factor alpha (TNF-alphalfa) and chemokine interferon-inducible protein-10 (IP-10). These results indicate the involvement of MIF in inflammatory responses to H5N1 influenza virus infections by induction of pulmonary inflammatory cytokines and chemokines, and suggest that pharmacotherapeutic approaches targeting MIF may hold promise for the treatment of H5N1 influenza virus pneumonia. |Animals[MESH] |Chemokines/immunology[MESH] |Cytokines/immunology[MESH] |Female[MESH] |Inflammation/immunology[MESH] |Influenza A Virus, H5N1 Subtype/*pathogenicity[MESH] |Intramolecular Oxidoreductases/*blood/metabolism[MESH] |Isoxazoles/administration & dosage[MESH] |Lung/immunology/*metabolism[MESH] |Macrophage Migration-Inhibitory Factors/*blood/metabolism[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Orthomyxoviridae Infections/immunology/*physiopathology/virology[MESH] |Pneumonia, Viral/immunology/*physiopathology/virology[MESH]Role of macrophage migration inhibitory factor in influenza H5N1 virus(epmc).pdf DeepDyve Pubget Overpricing