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10.1139/y09-090 http://scihub22266oqcxt.onion/10.1139/y09-090 19935903!ä!19935903 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Can+J+Physiol+Pharmacol 2009 ; 87 (11): 954-62 Nephropedia Template TP {{tp|p=19935903|t=2009. Inhibitory effects of dauricine on early afterdepolarizations and L-type calcium current |pdf=|usr=}}{{19935903}} gab.com Text Inhibitory effects of dauricine on early afterdepolarizations and L-type calcium current JO: Can J Physiol Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=19935903 #FOAvip We have previously reported that dauricine exerted antiarrhythmic effects on various experimental arrhythmias. To further clarify its mechanism, the effects of dauricine on action potential duration (APD), early afterdepolarizations (EADs), triangulation, which is defined as the repolarization time from APD at 30% level (APD30) to APD at 90% level (APD90), and L-type calcium current (I(Ca-L)) were studied using standard microelectrode techniques on rabbit papillary muscles and whole-cell patch clamp techniques on single myocytes isolated from rabbits by enzymatic digestion, respectively. Cardiac hypertrophy was induced by coarctating the abdominal aorta of rabbits. The results showed that in papillary muscles of hypertrophied rabbits, 1 micromol/L dofetilide, a selective IKr blocker, prolonged APD50 and APD90 and induced EADs (4/6, p < 0.01) with hypokalemia ([K+]o = 2.7 mmol/L). Dauricine inhibited EADs (p < 0.01) and shortened the prolonged APD (p < 0.01). In single myocytes, dauricine also inhibited EADs induced by dofetilide, hypokalemia, and hypomagnesaemia. Dauricine decreased the triangulation and reduced the peak amplitude of I(Ca-L) at all potentials tested. Dauricine shifted the steady-state activation curves to the right and steady-state inactivation curves to the left and prolonged the tau value of the recovery curve. These results suggest that dauricine inhibits EADs and this effect may be associated with its blockade of I(Ca-L). Twit Text FOAVip Inhibitory effects of dauricine on early afterdepolarizations and L-type calcium current ????Can J Physiol Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=19935903 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19935903 #FOAvip English Wikipedia <ref>{{Cite pmid|19935903}}</ref> Inhibitory effects of dauricine on early afterdepolarizations and L-type calcium current #MMPMID19935903 Liu QN; Zhang L; Gong PL; Yang XY; Zeng FD Can J Physiol Pharmacol 2009[Nov]; 87 (11): 954-62 PMID19935903show ga We have previously reported that dauricine exerted antiarrhythmic effects on various experimental arrhythmias. To further clarify its mechanism, the effects of dauricine on action potential duration (APD), early afterdepolarizations (EADs), triangulation, which is defined as the repolarization time from APD at 30% level (APD30) to APD at 90% level (APD90), and L-type calcium current (I(Ca-L)) were studied using standard microelectrode techniques on rabbit papillary muscles and whole-cell patch clamp techniques on single myocytes isolated from rabbits by enzymatic digestion, respectively. Cardiac hypertrophy was induced by coarctating the abdominal aorta of rabbits. The results showed that in papillary muscles of hypertrophied rabbits, 1 micromol/L dofetilide, a selective IKr blocker, prolonged APD50 and APD90 and induced EADs (4/6, p < 0.01) with hypokalemia ([K+]o = 2.7 mmol/L). Dauricine inhibited EADs (p < 0.01) and shortened the prolonged APD (p < 0.01). In single myocytes, dauricine also inhibited EADs induced by dofetilide, hypokalemia, and hypomagnesaemia. Dauricine decreased the triangulation and reduced the peak amplitude of I(Ca-L) at all potentials tested. Dauricine shifted the steady-state activation curves to the right and steady-state inactivation curves to the left and prolonged the tau value of the recovery curve. These results suggest that dauricine inhibits EADs and this effect may be associated with its blockade of I(Ca-L). |Action Potentials/drug effects[MESH] |Animals[MESH] |Anti-Arrhythmia Agents/*pharmacology[MESH] |Benzylisoquinolines/*pharmacology[MESH] |Calcium Channel Blockers/*pharmacology[MESH] |Calcium Channels, L-Type/*metabolism[MESH] |Dose-Response Relationship, Drug[MESH] |Female[MESH] |Hypertrophy, Left Ventricular/*physiopathology[MESH] |In Vitro Techniques[MESH] |Long QT Syndrome/chemically induced[MESH] |Magnesium/metabolism[MESH] |Male[MESH] |Myocytes, Cardiac/drug effects[MESH] |Neuromuscular Depolarizing Agents/*pharmacology[MESH] |Papillary Muscles/*drug effects[MESH] |Patch-Clamp Techniques[MESH] |Phenethylamines/pharmacology[MESH] |Potassium Channel Blockers/pharmacology[MESH] |Potassium/metabolism[MESH] |Rabbits[MESH] |Sulfonamides/pharmacology[MESH]Inhibitory effects of dauricine on early afterdepolarizations and L-ty(epmc).pdf DeepDyve Pubget Overpricing