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10.1152/ajprenal.00608.2009 http://scihub22266oqcxt.onion/10.1152/ajprenal.00608.2009 19923405!2838589!19923405     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Renal+Physiol 2010 ; 298 (3): F485-99 Nephropedia Template TP {{tp|p=19923405|t=2010. Physiology and pathophysiology of the calcium-sensing receptor in the kidney |pdf=|usr=}}{{19923405}} gab.com Text Physiology and pathophysiology of the calcium-sensing receptor in the kidney JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=19923405 #FOAvip The extracellular calcium-sensing receptor (CaSR) plays a major role in the maintenance of a physiological serum ionized calcium (Ca2+) concentration by regulating the circulating levels of parathyroid hormone. It was molecularly identified in 1993 by Brown et al. in the laboratory of Dr. Steven Hebert with an expression cloning strategy. Subsequent studies have demonstrated that the CaSR is highly expressed in the kidney, where it is capable of integrating signals deriving from the tubular fluid and/or the interstitial plasma. Additional studies elucidating inherited and acquired mutations in the CaSR gene, the existence of activating and inactivating autoantibodies, and genetic polymorphisms of the CaSR have greatly enhanced our understanding of the role of the CaSR in mineral ion metabolism. Allosteric modulators of the CaSR are the first drugs in their class to become available for clinical use and have been shown to treat successfully hyperparathyroidism secondary to advanced renal failure. In addition, preclinical and clinical studies suggest the possibility of using such compounds in various forms of hypercalcemic hyperparathyroidism, such as primary and lithium-induced hyperparathyroidism and that occurring after renal transplantation. This review addresses the role of the CaSR in kidney physiology and pathophysiology as well as current and in-the-pipeline treatments utilizing CaSR-based therapeutics. Twit Text FOAVip Physiology and pathophysiology of the calcium-sensing receptor in the kidney ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=19923405 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19923405 #FOAvip English Wikipedia <ref>{{Cite pmid|19923405}}</ref> Physiology and pathophysiology of the calcium-sensing receptor in the kidney #MMPMID19923405 Riccardi D; Brown EM Am J Physiol Renal Physiol 2010[Mar]; 298 (3): F485-99 PMID19923405show ga The extracellular calcium-sensing receptor (CaSR) plays a major role in the maintenance of a physiological serum ionized calcium (Ca2+) concentration by regulating the circulating levels of parathyroid hormone. It was molecularly identified in 1993 by Brown et al. in the laboratory of Dr. Steven Hebert with an expression cloning strategy. Subsequent studies have demonstrated that the CaSR is highly expressed in the kidney, where it is capable of integrating signals deriving from the tubular fluid and/or the interstitial plasma. Additional studies elucidating inherited and acquired mutations in the CaSR gene, the existence of activating and inactivating autoantibodies, and genetic polymorphisms of the CaSR have greatly enhanced our understanding of the role of the CaSR in mineral ion metabolism. Allosteric modulators of the CaSR are the first drugs in their class to become available for clinical use and have been shown to treat successfully hyperparathyroidism secondary to advanced renal failure. In addition, preclinical and clinical studies suggest the possibility of using such compounds in various forms of hypercalcemic hyperparathyroidism, such as primary and lithium-induced hyperparathyroidism and that occurring after renal transplantation. This review addresses the role of the CaSR in kidney physiology and pathophysiology as well as current and in-the-pipeline treatments utilizing CaSR-based therapeutics. |*Signal Transduction/drug effects[MESH] |Animals[MESH] |Autoantibodies/blood[MESH] |Bartter Syndrome/metabolism/physiopathology[MESH] |Calcium/*metabolism[MESH] |Homeostasis[MESH] |Humans[MESH] |Hypercalcemia/metabolism/physiopathology[MESH] |Hypercalciuria/metabolism/physiopathology[MESH] |Hyperparathyroidism, Primary/metabolism/physiopathology[MESH] |Kidney/drug effects/*metabolism/physiopathology[MESH] |Mutation[MESH] |Parathyroid Glands/metabolism[MESH] |Parathyroid Hormone/metabolism[MESH] |Protein Conformation[MESH] |Receptors, Calcium-Sensing/drug effects/genetics/immunology/*metabolism[MESH]Physiology and pathophysiology of the calcium-sensing receptor in the (epmc).pdf DeepDyve Pubget Overpricing