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10.3109/08977190903152644 http://scihub22266oqcxt.onion/10.3109/08977190903152644 19919525!ä!19919525 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Growth+Factors 2009 ; 27 (6): 370-6 Nephropedia Template TP {{tp|p=19919525|t=2009. TNFalpha receptor knockout in mice reduces adverse effects of magnesium deficiency on bone |pdf=|usr=}}{{19919525}} gab.com Text TNFalpha receptor knockout in mice reduces adverse effects of magnesium deficiency on bone JO: Growth Factors http://www.kidney.de/pget.php?&tw=1&pmid=19919525 #FOAvip Epidemiologic studies have linked low dietary magnesium (Mg) intake to osteoporosis. Dietary Mg restriction in animal models has demonstrated a decrease in bone mass and an increase in skeletal fragility. The exact mechanism for the decrease in bone mass is not clear but a decrease in osteoblast number and an increase in osteoclast number (Oc.No/B.Pm) suggests an uncoupling of bone formation and bone resorption favoring skeletal loss. Mg depletion results in an increase in inflammatory cytokines, which could explain the increase in bone resorption. We have previously demonstrated an increase in TNFalpha in bone from Mg deficient rodents. Here we report results of a 3 week study of a low magnesium (LM) diet and normal Mg diet in 35-day-old TNFalpha receptor knockout mice (TNF-r-KO) versus wild type (WT) control mice. Our results indicated that a LM diet resulted in a greater increase in Oc.No/B.Pm in the WT mice, with a trend toward greater eroded bone perimeter, as compared to TNF-r-KO. These findings suggest that TNFalpha may play a role in Mg deficiency-induced bone loss. Twit Text FOAVip TNFalpha receptor knockout in mice reduces adverse effects of magnesium deficiency on bone ????Growth Factors http://www.kidney.de/pget.php?&tw=1&pmid=19919525 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19919525 #FOAvip English Wikipedia <ref>{{Cite pmid|19919525}}</ref> TNFalpha receptor knockout in mice reduces adverse effects of magnesium deficiency on bone #MMPMID19919525 Rude RK; Wei L; Norton HJ; Lu SS; Dempster DW; Gruber HE Growth Factors 2009[Dec]; 27 (6): 370-6 PMID19919525show ga Epidemiologic studies have linked low dietary magnesium (Mg) intake to osteoporosis. Dietary Mg restriction in animal models has demonstrated a decrease in bone mass and an increase in skeletal fragility. The exact mechanism for the decrease in bone mass is not clear but a decrease in osteoblast number and an increase in osteoclast number (Oc.No/B.Pm) suggests an uncoupling of bone formation and bone resorption favoring skeletal loss. Mg depletion results in an increase in inflammatory cytokines, which could explain the increase in bone resorption. We have previously demonstrated an increase in TNFalpha in bone from Mg deficient rodents. Here we report results of a 3 week study of a low magnesium (LM) diet and normal Mg diet in 35-day-old TNFalpha receptor knockout mice (TNF-r-KO) versus wild type (WT) control mice. Our results indicated that a LM diet resulted in a greater increase in Oc.No/B.Pm in the WT mice, with a trend toward greater eroded bone perimeter, as compared to TNF-r-KO. These findings suggest that TNFalpha may play a role in Mg deficiency-induced bone loss. |Animals[MESH] |Bone Resorption/*etiology[MESH] |Disease Models, Animal[MESH] |Femur/metabolism/pathology[MESH] |Magnesium Deficiency/*complications/metabolism[MESH] |Magnesium/metabolism/*pharmacology[MESH] |Mice[MESH] |Mice, Knockout[MESH] |Osteoclasts/cytology/metabolism[MESH] |Receptors, Tumor Necrosis Factor/*genetics[MESH]TNFalpha receptor knockout in mice reduces adverse effects of magnesiu(epmc).pdf DeepDyve Pubget Overpricing