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10.1016/j.biopsych.2009.09.028 http://scihub22266oqcxt.onion/10.1016/j.biopsych.2009.09.028 19914600/?report=reader!2900781!19914600     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biol+Psychiatry 2010 ; 67 (4): 386-92 Nephropedia Template TP {{tp|p=19914600|t=2010. Neonatal intrahippocampal immune challenge alters dopamine modulation of prefrontal cortical interneurons in adult rats |pdf=|usr=}}{{19914600}} gab.com Text Neonatal intrahippocampal immune challenge alters dopamine modulation of prefrontal cortical interneurons in adult rats JO: Biol Psychiatry http://www.kidney.de/pget.php?&tw=1&pmid=19914600 #FOAvip BACKGROUND: Among the diverse animal models proposed for schizophrenia, the neonatal ventral hippocampal lesion (NVHL) is one of the most widely used. However, its construct validity can be questioned because there is no evidence of a lesion present in schizophrenia. Other approaches that have tried to capture environmental influences on development include diverse models of maternal infection. METHODS: As the early postnatal days in rodents are equivalent to the third trimester of human pregnancy in terms of brain development, we decided to test whether a neonatal immune challenge with an injection of the bacterial endotoxin lipopolysaccharide (LPS) into the ventral hippocampus caused deficits in interneuron function similar to those reported for the NVHL. RESULTS: Neonatal LPS injection caused a persistent elevation in cytokines in several brain regions, deficits in prepulse inhibition of the acoustic startle response, and a loss of the periadolescent maturation in the response of prefrontal cortical fast-spiking interneurons to dopamine. CONCLUSIONS: The same phenotypes elicited by a NVHL can be obtained with an intrahippocampal immune challenge, suggesting that perinatal environmental factors can affect adult prefrontal interneuron maturation during adolescence. Twit Text FOAVip Neonatal intrahippocampal immune challenge alters dopamine modulation of prefrontal cortical interneurons in adult rats ????Biol Psychiatry http://www.kidney.de/pget.php?&tw=1&pmid=19914600 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19914600 #FOAvip English Wikipedia <ref>{{Cite pmid|19914600}}</ref> Neonatal intrahippocampal immune challenge alters dopamine modulation of prefrontal cortical interneurons in adult rats #MMPMID19914600 Feleder C; Tseng KY; Calhoon GG; O'Donnell P Biol Psychiatry 2010[Feb]; 67 (4): 386-92 PMID19914600show ga BACKGROUND: Among the diverse animal models proposed for schizophrenia, the neonatal ventral hippocampal lesion (NVHL) is one of the most widely used. However, its construct validity can be questioned because there is no evidence of a lesion present in schizophrenia. Other approaches that have tried to capture environmental influences on development include diverse models of maternal infection. METHODS: As the early postnatal days in rodents are equivalent to the third trimester of human pregnancy in terms of brain development, we decided to test whether a neonatal immune challenge with an injection of the bacterial endotoxin lipopolysaccharide (LPS) into the ventral hippocampus caused deficits in interneuron function similar to those reported for the NVHL. RESULTS: Neonatal LPS injection caused a persistent elevation in cytokines in several brain regions, deficits in prepulse inhibition of the acoustic startle response, and a loss of the periadolescent maturation in the response of prefrontal cortical fast-spiking interneurons to dopamine. CONCLUSIONS: The same phenotypes elicited by a NVHL can be obtained with an intrahippocampal immune challenge, suggesting that perinatal environmental factors can affect adult prefrontal interneuron maturation during adolescence. |Acoustic Stimulation/adverse effects[MESH] |Action Potentials/drug effects[MESH] |Animals[MESH] |Animals, Newborn[MESH] |Cytokines/metabolism[MESH] |Dopamine Agonists/pharmacology[MESH] |Dopamine/*pharmacology[MESH] |Enzyme-Linked Immunosorbent Assay/methods[MESH] |Gene Expression Regulation, Developmental/drug effects/physiology[MESH] |Hippocampus/drug effects/*immunology[MESH] |Interneurons/*drug effects/physiology[MESH] |Lipopolysaccharides/pharmacology[MESH] |Neural Inhibition/drug effects/physiology[MESH] |Patch-Clamp Techniques[MESH] |Prefrontal Cortex/*cytology/drug effects[MESH] |Quinpirole/pharmacology[MESH] |Rats[MESH]Neonatal intrahippocampal immune challenge alters dopamine modulation (epmc).pdf DeepDyve Pubget Overpricing