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10.1208/s12249-009-9316-0 http://scihub22266oqcxt.onion/10.1208/s12249-009-9316-0 19862626KneadingTechniqueforPreparationofBinarySolidDispersionofMeloxicamwithPoloxamer188.!2799582!19862626; 188     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=19862626; 188&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 400 Bad Request in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       AAPS+PharmSciTech;+Comp+Biochem+Physiol+A+Comp+Physiol 2009 ; 10; 53 (4; 1): 1206-15; 69-72 Nephropedia Template TP {{tp|p=19862626; 188|t=2009. Kneading technique for preparation of binary solid dispersion of meloxicam with poloxamer 188 ; Diving bradycardia in four species of North American aquatic snakes |pdf=|usr=}}{{19862626; 188}} gab.com Text Kneading technique for preparation of binary solid dispersion of meloxicam with poloxamer 188 ; Diving bradycardia in four species of North American aquatic snakes JO: AAPS PharmSciTech; Comp Biochem Physiol A Comp Physiol http://www.kidney.de/pget.php?&tw=1&pmid=19862626; 188 #FOAvip The aim of the present study was to enhance the dissolution rate of meloxicam (MLX), a practically water-insoluble drug by preparation of solid dispersion using a hydrophilic polymer, poloxamer 188 (PXM). The kneading technique was used to prepare solid dispersions. A 3(2) full factorial design approach was used for optimization wherein the drug, polymer ratio (X1), and the kneading time (X2) were selected as independent variables and the dissolution efficiency at 60 min (%DE60) and yield percent were selected as the dependent variable. Multiple linear regression analysis revealed that for obtaining higher dissolution of MLX from PXM solid dispersions, a high level of X1 and a high level of X2 were suitable. The use of a factorial design approach helped in optimization of the preparation and formulation of solid dispersion. The optimized formula was characterized by solubility studies, angle of repose, and contact angle; Fourier transform infrared spectroscopy, differential scanning calorimetry, x-ray diffraction studies, and scanning electron microscopy demonstrated that enhanced dissolution of MLX from solid dispersion might be due to a decrease in the crystallinity of MLX and PXM. Analysis of dissolution data of optimized formula indicated the best fitting with Korsemeyer-Peppas model and the drug release kinetics as Fickian diffusion. In conclusion, dissolution enhancement of MLX was obtained by preparing its solid dispersion with PXM using kneading technique. Twit Text FOAVip Kneading technique for preparation of binary solid dispersion of meloxicam with poloxamer 188 ; Diving bradycardia in four species of North American aquatic snakes ????AAPS PharmSciTech; Comp Biochem Physiol A Comp Physiol http://www.kidney.de/pget.php?&tw=1&pmid=19862626; 188 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19862626; 188 #FOAvip English Wikipedia <ref>{{Cite pmid|19862626; 188}}</ref> Kneading technique for preparation of binary solid dispersion of meloxicam with poloxamer 188 ; Diving bradycardia in four species of North American aquatic snakes #MMPMID19862626; 188 Ghareeb MM; Abdulrasool AA; Hussein AA; Noordin MI; Jacob JS; McDonald HS AAPS PharmSciTech; Comp Biochem Physiol A Comp Physiol 2009[ 19]; 10; 53 (4; 1): 1206-15; 69-72 PMID19862626; 188show ga The aim of the present study was to enhance the dissolution rate of meloxicam (MLX), a practically water-insoluble drug by preparation of solid dispersion using a hydrophilic polymer, poloxamer 188 (PXM). The kneading technique was used to prepare solid dispersions. A 3(2) full factorial design approach was used for optimization wherein the drug, polymer ratio (X1), and the kneading time (X2) were selected as independent variables and the dissolution efficiency at 60 min (%DE60) and yield percent were selected as the dependent variable. Multiple linear regression analysis revealed that for obtaining higher dissolution of MLX from PXM solid dispersions, a high level of X1 and a high level of X2 were suitable. The use of a factorial design approach helped in optimization of the preparation and formulation of solid dispersion. The optimized formula was characterized by solubility studies, angle of repose, and contact angle; Fourier transform infrared spectroscopy, differential scanning calorimetry, x-ray diffraction studies, and scanning electron microscopy demonstrated that enhanced dissolution of MLX from solid dispersion might be due to a decrease in the crystallinity of MLX and PXM. Analysis of dissolution data of optimized formula indicated the best fitting with Korsemeyer-Peppas model and the drug release kinetics as Fickian diffusion. In conclusion, dissolution enhancement of MLX was obtained by preparing its solid dispersion with PXM using kneading technique. |*Diving[MESH] |*Heart Rate[MESH] |*Technology, Pharmaceutical[MESH] |Animals[MESH] |Anti-Inflammatory Agents, Non-Steroidal/*chemistry[MESH] |Calorimetry, Differential Scanning[MESH] |Electrocardiography[MESH] |Meloxicam[MESH] |Microscopy, Electron, Scanning[MESH] |Poloxamer/*chemistry[MESH] |Snakes/*physiology[MESH] |Solubility[MESH] |Species Specificity[MESH] |Spectroscopy, Fourier Transform Infrared[MESH] |Thiazines/*chemistry[MESH] |Thiazoles/*chemistry[MESH]Kneading technique for preparation of binary solid dispersion of melox(epmc).pdf DeepDyve Pubget Overpricing