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10.1208/s12248-009-9146-8 http://scihub22266oqcxt.onion/10.1208/s12248-009-9146-8 19859815/?report=reader!2782080!19859815     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       AAPS+J 2009 ; 11 (4): 710-27 Nephropedia Template TP {{tp|p=19859815|t=2009. Herb-drug interactions with St John s wort (Hypericum perforatum): an update on clinical observations |pdf=|usr=}}{{19859815}} gab.com Text Herb-drug interactions with St John s wort (Hypericum perforatum): an update on clinical observations JO: AAPS J http://www.kidney.de/pget.php?&tw=1&pmid=19859815 #FOAvip St John's wort (SJW) extracts, prepared from the aerial parts of Hypericum perforatum, contain numerous pharmacologically active ingredients, including naphthodianthrones (e.g., hypericin and its derivatives), phloroglucinols derivatives (e.g., hyperforin, which inhibits the reuptake of a number of neurotransmitters, including serotonin), and flavonoids. Such extracts are widely used for the treatment of mild-to-moderate depression. As a monotherapy, SJW has an encouraging safety profile. However, relevant and, in some case, life-threatening interactions have been reported, particularly with drugs which are substrate of cytochrome P450 and/or P-glycoprotein. Well-documented SJW interactions include (1) reduced blood cyclosporin concentration, as suggested by multiple case reports as well as by clinical trials, (2) serotonin syndrome or lethargy when SJW was given with serotonin reuptake inhibitors, (3) unwanted pregnancies in women while using oral contraceptives and SJW, and (4) reduced plasma drug concentration of antiretroviral (e.g., indinavir, nevirapine) and anticancer (i.e., irinotecan, imatinib) drugs. Hyperforin, which is believed to contribute to the antidepressant action of St John's wort, is also strongly suspected to be responsible of most of the described interactions. Twit Text FOAVip Herb-drug interactions with St John s wort (Hypericum perforatum): an update on clinical observations ????AAPS J http://www.kidney.de/pget.php?&tw=1&pmid=19859815 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19859815 #FOAvip English Wikipedia <ref>{{Cite pmid|19859815}}</ref> Herb-drug interactions with St John s wort (Hypericum perforatum): an update on clinical observations #MMPMID19859815 Borrelli F; Izzo AA AAPS J 2009[Dec]; 11 (4): 710-27 PMID19859815show ga St John's wort (SJW) extracts, prepared from the aerial parts of Hypericum perforatum, contain numerous pharmacologically active ingredients, including naphthodianthrones (e.g., hypericin and its derivatives), phloroglucinols derivatives (e.g., hyperforin, which inhibits the reuptake of a number of neurotransmitters, including serotonin), and flavonoids. Such extracts are widely used for the treatment of mild-to-moderate depression. As a monotherapy, SJW has an encouraging safety profile. However, relevant and, in some case, life-threatening interactions have been reported, particularly with drugs which are substrate of cytochrome P450 and/or P-glycoprotein. Well-documented SJW interactions include (1) reduced blood cyclosporin concentration, as suggested by multiple case reports as well as by clinical trials, (2) serotonin syndrome or lethargy when SJW was given with serotonin reuptake inhibitors, (3) unwanted pregnancies in women while using oral contraceptives and SJW, and (4) reduced plasma drug concentration of antiretroviral (e.g., indinavir, nevirapine) and anticancer (i.e., irinotecan, imatinib) drugs. Hyperforin, which is believed to contribute to the antidepressant action of St John's wort, is also strongly suspected to be responsible of most of the described interactions. |ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism[MESH] |Animals[MESH] |Cytochrome P-450 Enzyme System/metabolism[MESH] |Drug Interactions[MESH] |Humans[MESH]Herb-drug interactions with St John s wort (Hypericum perforatum): an (epmc).pdf DeepDyve Pubget Overpricing