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10.1016/j.bbadis.2009.10.004 http://scihub22266oqcxt.onion/10.1016/j.bbadis.2009.10.004 19835956/?report=reader!2888861!19835956     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=19835956&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochim+Biophys+Acta 2010 ; 1802 (10): 903-17 Nephropedia Template TP {{tp|p=19835956|t=2010. Transgenic models for cytokine-induced neurological disease |pdf=|usr=}}{{19835956}} gab.com Text Transgenic models for cytokine-induced neurological disease JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=19835956 #FOAvip Considerable evidence supports the idea that cytokines are important mediators of pathophysiologic processes within the central nervous system (CNS). Numerous studies have documented the increased production of various cytokines in the human CNS in a variety of neurological and neuropsychiatric disorders. Deciphering cytokine actions in the intact CNS has important implications for our understanding of the pathogenesis and treatment of these disorders. One approach to address this problem that has been used widely employs transgenic mice with CNS-targeted production of different cytokines. Transgenic production of cytokines in the CNS of mice allows not only for the investigation of complex cellular responses at a localized level in the intact brain but also more closely recapitulates the expression of these mediators as found in disease states. As discussed in this review, the findings show that these transgenic animals exhibit wide-ranging structural and functional deficits that are linked to the development of distinct neuroinflammatory responses which are relatively specific for each cytokine. These cytokine-induced alterations often recapitulate those found in various human neurological disorders not only underscoring the relevance of these models but also reinforcing the clinicopathogenetic significance of cytokines in diseases of the CNS. Twit Text FOAVip Transgenic models for cytokine-induced neurological disease ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=19835956 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19835956 #FOAvip English Wikipedia <ref>{{Cite pmid|19835956}}</ref> Transgenic models for cytokine-induced neurological disease #MMPMID19835956 Campbell IL; Hofer MJ; Pagenstecher A Biochim Biophys Acta 2010[Oct]; 1802 (10): 903-17 PMID19835956show ga Considerable evidence supports the idea that cytokines are important mediators of pathophysiologic processes within the central nervous system (CNS). Numerous studies have documented the increased production of various cytokines in the human CNS in a variety of neurological and neuropsychiatric disorders. Deciphering cytokine actions in the intact CNS has important implications for our understanding of the pathogenesis and treatment of these disorders. One approach to address this problem that has been used widely employs transgenic mice with CNS-targeted production of different cytokines. Transgenic production of cytokines in the CNS of mice allows not only for the investigation of complex cellular responses at a localized level in the intact brain but also more closely recapitulates the expression of these mediators as found in disease states. As discussed in this review, the findings show that these transgenic animals exhibit wide-ranging structural and functional deficits that are linked to the development of distinct neuroinflammatory responses which are relatively specific for each cytokine. These cytokine-induced alterations often recapitulate those found in various human neurological disorders not only underscoring the relevance of these models but also reinforcing the clinicopathogenetic significance of cytokines in diseases of the CNS. |*Disease Models, Animal[MESH] |Animals[MESH] |Cytokines/*metabolism[MESH] |Humans[MESH] |Mice[MESH] |Mice, Transgenic[MESH]Transgenic models for cytokine-induced neurological disease (epmc).pdf DeepDyve Pubget Overpricing