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10.1186/1471-2164-10-476 http://scihub22266oqcxt.onion/10.1186/1471-2164-10-476 19832994!2766392!19832994     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=19832994&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Genomics 2009 ; 10 (ä): 476 Nephropedia Template TP {{tp|p=19832994|t=2009. Identification of novel androgen-responsive genes by sequencing of LongSAGE libraries |pdf=|usr=}}{{19832994}} gab.com Text Identification of novel androgen-responsive genes by sequencing of LongSAGE libraries JO: BMC Genomics http://www.kidney.de/pget.php?&tw=1&pmid=19832994 #FOAvip BACKGROUND: The development and maintenance of the prostate is dependent on androgens and the androgen receptor. The androgen pathway continues to be important in prostate cancer. Here, we evaluated the transcriptome of prostate cancer cells in response to androgen using long serial analysis of gene expression (LongSAGE) libraries. RESULTS: There were 131 tags (87 genes) that displayed statistically significant (p <or= 0.001) differences in expression in response to androgen. Many of the genes identified by LongSAGE (35/87) have not been previously reported to change expression in the direction or sense observed. In regulatory regions of the promoter and/or enhancer regions of some of these genes there are confirmed or potential androgen response elements (AREs). The expression trends of 24 novel genes were validated using quantitative real time-polymerase chain reaction (qRT-PCR). These genes were: ARL6IP5, BLVRB, C19orf48, C1orf122, C6orf66, CAMK2N1, CCNI, DERA, ERRFI1, GLUL, GOLPH3, HM13, HSP90B1, MANEA, NANS, NIPSNAP3A, SLC41A1, SOD1, SVIP, TAOK3, TCP1, TMEM66, USP33, and VTA1. The physiological relevance of these expression trends was evaluated in vivo using the LNCaP Hollow Fibre model. Novel androgen-responsive genes identified here participate in protein synthesis and trafficking, response to oxidative stress, transcription, proliferation, apoptosis, and differentiation. CONCLUSION: These processes may represent the molecular mechanisms of androgen-dependency of the prostate. Genes that participate in these pathways may be targets for therapies or biomarkers of prostate cancer. Twit Text FOAVip Identification of novel androgen-responsive genes by sequencing of LongSAGE libraries ????BMC Genomics http://www.kidney.de/pget.php?&tw=1&pmid=19832994 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19832994 #FOAvip English Wikipedia <ref>{{Cite pmid|19832994}}</ref> Identification of novel androgen-responsive genes by sequencing of LongSAGE libraries #MMPMID19832994 Romanuik TL; Wang G; Holt RA; Jones SJ; Marra MA; Sadar MD BMC Genomics 2009[Oct]; 10 (ä): 476 PMID19832994show ga BACKGROUND: The development and maintenance of the prostate is dependent on androgens and the androgen receptor. The androgen pathway continues to be important in prostate cancer. Here, we evaluated the transcriptome of prostate cancer cells in response to androgen using long serial analysis of gene expression (LongSAGE) libraries. RESULTS: There were 131 tags (87 genes) that displayed statistically significant (p |*Gene Expression Regulation, Neoplastic[MESH] |Androgens/*metabolism[MESH] |Animals[MESH] |Cell Line, Tumor[MESH] |Gene Expression Profiling/*methods[MESH] |Genes, Neoplasm[MESH] |Humans[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Mice, Nude[MESH] |Prostatic Neoplasms/*genetics[MESH]Identification of novel androgen-responsive genes by sequencing of Lon(epmc).pdf DeepDyve Pubget Overpricing