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10.1208/s12249-009-9306-2 http://scihub22266oqcxt.onion/10.1208/s12249-009-9306-2 19757079/?report=reader!2799572!19757079     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       AAPS+PharmSciTech 2009 ; 10 (4): 1093-103 Nephropedia Template TP {{tp|p=19757079|t=2009. Nanocarrier for the transdermal delivery of an antiparkinsonian drug |pdf=|usr=}}{{19757079}} gab.com Text Nanocarrier for the transdermal delivery of an antiparkinsonian drug JO: AAPS PharmSciTech http://www.kidney.de/pget.php?&tw=1&pmid=19757079 #FOAvip The purpose of the present study was to investigate the potential of nanoemulsions as nanodrug carrier systems for the percutaneous delivery of ropinirole. Nanoemulsions comprised Capryol 90 as the oil phase, Tween 20 as the surfactant, Carbitol as the cosurfactant, and water as an external phase. The effects of composition of nanoemulsion, including the ratio of surfactant and cosurfactant (Smix) and their concentration on skin permeation, were evaluated. All the prepared nanoemulsions showed a significant increase in permeation parameters such as steady state flux (Jss) and permeability coefficient (Kp) when compared to the control (p<0.01). Nanoemulsion composition (NEL3) comprising ropinirole (0.5% w/w), Capryol 90 (5% w/w), Smix 2:1 (35% w/w), and water (59.5% w/w) showed the highest flux (51.81+/-5.03 microg/cm2/h) and was selected for formulation into nanoemulsion gel. The gel was further optimized with respect to oil concentration (Capryol 90), polymer concentration (Carbopol), and drug content by employing the Box-Behnken design, which statistically evaluated the effects of these components on ropinirole permeation. Oil and polymer concentrations were found to have a negative influence on permeation, while the drug content had a positive effect. Nanoemulsion gel showed a 7.5-fold increase in skin permeation rate when compared to the conventional hydrogel. In conclusion, the results of the present investigation suggested a promising role of nanoemulsions in enhancing the transdermal permeation of ropinirole. Twit Text FOAVip Nanocarrier for the transdermal delivery of an antiparkinsonian drug ????AAPS PharmSciTech http://www.kidney.de/pget.php?&tw=1&pmid=19757079 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19757079 #FOAvip English Wikipedia <ref>{{Cite pmid|19757079}}</ref> Nanocarrier for the transdermal delivery of an antiparkinsonian drug #MMPMID19757079 Azeem A; Ahmad FJ; Khar RK; Talegaonkar S AAPS PharmSciTech 2009[]; 10 (4): 1093-103 PMID19757079show ga The purpose of the present study was to investigate the potential of nanoemulsions as nanodrug carrier systems for the percutaneous delivery of ropinirole. Nanoemulsions comprised Capryol 90 as the oil phase, Tween 20 as the surfactant, Carbitol as the cosurfactant, and water as an external phase. The effects of composition of nanoemulsion, including the ratio of surfactant and cosurfactant (Smix) and their concentration on skin permeation, were evaluated. All the prepared nanoemulsions showed a significant increase in permeation parameters such as steady state flux (Jss) and permeability coefficient (Kp) when compared to the control (p<0.01). Nanoemulsion composition (NEL3) comprising ropinirole (0.5% w/w), Capryol 90 (5% w/w), Smix 2:1 (35% w/w), and water (59.5% w/w) showed the highest flux (51.81+/-5.03 microg/cm2/h) and was selected for formulation into nanoemulsion gel. The gel was further optimized with respect to oil concentration (Capryol 90), polymer concentration (Carbopol), and drug content by employing the Box-Behnken design, which statistically evaluated the effects of these components on ropinirole permeation. Oil and polymer concentrations were found to have a negative influence on permeation, while the drug content had a positive effect. Nanoemulsion gel showed a 7.5-fold increase in skin permeation rate when compared to the conventional hydrogel. In conclusion, the results of the present investigation suggested a promising role of nanoemulsions in enhancing the transdermal permeation of ropinirole. |Administration, Cutaneous[MESH] |Animals[MESH] |Antiparkinson Agents/*administration & dosage[MESH] |Drug Carriers[MESH] |Emulsions[MESH] |Gels[MESH] |Indoles/*administration & dosage/chemistry/pharmacokinetics[MESH] |Male[MESH] |Rats[MESH] |Rats, Wistar[MESH] |Skin/metabolism[MESH]Nanocarrier for the transdermal delivery of an antiparkinsonian drug (epmc).pdf DeepDyve Pubget Overpricing