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10.1159/000238824

http://scihub22266oqcxt.onion/10.1159/000238824
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19752530!ä!19752530

suck abstract from ncbi


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pmid19752530      Am+J+Nephrol 2009 ; 30 (5): 425-9
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  • Uric acid: a novel risk factor for acute kidney injury in high-risk cardiac surgery patients? #MMPMID19752530
  • Ejaz AA; Beaver TM; Shimada M; Sood P; Lingegowda V; Schold JD; Kim T; Johnson RJ
  • Am J Nephrol 2009[]; 30 (5): 425-9 PMID19752530show ga
  • BACKGROUND: Uric acid has been reported to be a risk factor for the development of chronic kidney disease; however, no study has examined whether uric acid may confer a risk for acute kidney injury. METHODS: We investigated the relation between serum uric acid and the incidence of postoperative acute kidney injury in patients undergoing high-risk cardiovascular surgery (cardiac valve and aneurysm surgery). RESULTS: Following cardiovascular surgery, 18 of 58 patients (31%) developed acute kidney injury, with 11 of 24 (45.8%) in the elevated uric acid group (defined as >6 mg/dl) and 7 of 34 (20.5%) in the normal uric acid group (p = 0.05). After controlling for baseline renal function, left ventricular ejection fraction, use of nesiritide, type of surgery, and history of previous surgery, an elevated preoperative uric acid conferred a 4-fold risk for acute kidney injury (OR: 3.98, CI: 1.10-14.33, p = 0.035) and longer hospital stay (36.35 vs. 24.66 days, p = 0.009). CONCLUSION: This preliminary study suggests that uric acid may be a novel risk factor for acute kidney injury in patients undergoing high-risk cardiovascular surgery.
  • |Acute Kidney Injury/blood/*epidemiology/prevention & control[MESH]
  • |Aged[MESH]
  • |Aneurysm/surgery[MESH]
  • |Cardiovascular Surgical Procedures/*adverse effects/*statistics & numerical data[MESH]
  • |Female[MESH]
  • |Heart Valve Diseases/surgery[MESH]
  • |Humans[MESH]
  • |Incidence[MESH]
  • |Logistic Models[MESH]
  • |Male[MESH]
  • |Natriuretic Agents/therapeutic use[MESH]
  • |Natriuretic Peptide, Brain/therapeutic use[MESH]
  • |Postoperative Complications/blood/*epidemiology/prevention & control[MESH]
  • |Preoperative Care/statistics & numerical data[MESH]
  • |Randomized Controlled Trials as Topic/statistics & numerical data[MESH]
  • |Risk Factors[MESH]


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