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10.1097/MNH.0b013e32832f7002 http://scihub22266oqcxt.onion/10.1097/MNH.0b013e32832f7002 19724224!2907246!19724224     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Nephrol+Hypertens 2009 ; 18 (6): 539-45 Nephropedia Template TP {{tp|p=19724224|t=2009. Role of altered insulin signaling pathways in the pathogenesis of podocyte malfunction and microalbuminuria |pdf=|usr=}}{{19724224}} gab.com Text Role of altered insulin signaling pathways in the pathogenesis of podocyte malfunction and microalbuminuria JO: Curr Opin Nephrol Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=19724224 #FOAvip PURPOSE OF REVIEW: In diabetic nephropathy, insulin resistance and hyperinsulinemia correlate with the development of albuminuria. The possibility that altered insulin signaling in glomerular cells and particularly podocytes contributes to the development of diabetic nephropathy will be discussed. RECENT FINDINGS: Whereas normal podocytes take up glucose in response to insulin, diabetic podocytes become insulin resistant in experimental diabetic nephropathy prior to the development of significant albuminuria. Both clinical and experimental data suggest that insulin sensitizers may be renoprotective independent of their systemic effects on the metabolic control of diabetes. SUMMARY: We will review the clinical and experimental evidence that altered insulin signaling correlates with the development of diabetic nephropathy in both type 1 and type 2 diabetes, and that insulin sensitizers may be superior to other hypoglycemic agents in the prevention of diabetic nephropathy. We will then review potential mechanisms by which altered podocyte insulin signaling may contribute to the development of diabetic nephropathy. Understanding the role of podocytes in glucose metabolism is important because it may lead to the discovery of novel pathogenetic mechanisms of diabetic nephropathy, it may affect current strategies for prevention and treatment of diabetic nephropathy, and it may allow the identification of novel therapeutic targets. Twit Text FOAVip Role of altered insulin signaling pathways in the pathogenesis of podocyte malfunction and microalbuminuria ????Curr Opin Nephrol Hypertens http://www.kidney.de/pget.php?&tw=1&pmid=19724224 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19724224 #FOAvip English Wikipedia <ref>{{Cite pmid|19724224}}</ref> Role of altered insulin signaling pathways in the pathogenesis of podocyte malfunction and microalbuminuria #MMPMID19724224 Jauregui A; Mintz DH; Mundel P; Fornoni A Curr Opin Nephrol Hypertens 2009[Nov]; 18 (6): 539-45 PMID19724224show ga PURPOSE OF REVIEW: In diabetic nephropathy, insulin resistance and hyperinsulinemia correlate with the development of albuminuria. The possibility that altered insulin signaling in glomerular cells and particularly podocytes contributes to the development of diabetic nephropathy will be discussed. RECENT FINDINGS: Whereas normal podocytes take up glucose in response to insulin, diabetic podocytes become insulin resistant in experimental diabetic nephropathy prior to the development of significant albuminuria. Both clinical and experimental data suggest that insulin sensitizers may be renoprotective independent of their systemic effects on the metabolic control of diabetes. SUMMARY: We will review the clinical and experimental evidence that altered insulin signaling correlates with the development of diabetic nephropathy in both type 1 and type 2 diabetes, and that insulin sensitizers may be superior to other hypoglycemic agents in the prevention of diabetic nephropathy. We will then review potential mechanisms by which altered podocyte insulin signaling may contribute to the development of diabetic nephropathy. Understanding the role of podocytes in glucose metabolism is important because it may lead to the discovery of novel pathogenetic mechanisms of diabetic nephropathy, it may affect current strategies for prevention and treatment of diabetic nephropathy, and it may allow the identification of novel therapeutic targets. |*Insulin Resistance[MESH] |*Signal Transduction/drug effects[MESH] |Albuminuria/*metabolism/physiopathology/prevention & control[MESH] |Animals[MESH] |Blood Glucose/metabolism[MESH] |Diabetic Nephropathies/*metabolism/physiopathology/prevention & control[MESH] |Humans[MESH] |Hyperinsulinism/metabolism/physiopathology[MESH] |Hypoglycemic Agents/therapeutic use[MESH] |Insulin/*metabolism[MESH] |Kidney/*metabolism/physiopathology[MESH]Role of altered insulin signaling pathways in the pathogenesis of podo(epmc).pdf DeepDyve Pubget Overpricing