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10.1016/j.addr.2009.06.008 http://scihub22266oqcxt.onion/10.1016/j.addr.2009.06.008 19716396!2784017!19716396     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Drug+Deliv+Rev 2009 ; 61 (14): 1375-85 Nephropedia Template TP {{tp|p=19716396|t=2009. Mitochondrial targeting of electron scavenging antioxidants: Regulation of selective oxidation vs random chain reactions |pdf=|usr=}}{{19716396}} gab.com Text Mitochondrial targeting of electron scavenging antioxidants: Regulation of selective oxidation vs random chain reactions JO: Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=19716396 #FOAvip Effective regulation of highly compartmentalized production of reactive oxygen species and peroxidation reactions in mitochondria requires targeting of small molecule antioxidants and antioxidant enzymes into the organelles. This review describes recently developed approaches to mitochondrial targeting of small biologically active molecules based on: (i) preferential accumulation in mitochondria because of their hydrophobicity and positive charge (hydrophobic cations), (ii) binding with high affinity to an intra-mitochondrial constituent, and (iii) metabolic conversions by specific mitochondrial enzymes to reveal an active entity. In addition, targeted delivery of antioxidant enzymes via expression of leader sequences directing the proteins into mitochondria is considered. Examples of successful antioxidant and anti-apoptotic protection based on the ability of targeted cargoes to inhibit cytochrome c-catalyzed peroxidation of a mitochondria-specific phospholipid cardiolipin, in vitro and in vivo are presented. Particular emphasis is placed on the employment of triphenylphosphonium- and hemi-gramicidin S-moieties as two effective vehicles for mitochondrial delivery of antioxidants. Twit Text FOAVip Mitochondrial targeting of electron scavenging antioxidants: Regulation of selective oxidation vs random chain reactions ????Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=19716396 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19716396 #FOAvip English Wikipedia <ref>{{Cite pmid|19716396}}</ref> Mitochondrial targeting of electron scavenging antioxidants: Regulation of selective oxidation vs random chain reactions #MMPMID19716396 Kagan VE; Wipf P; Stoyanovsky D; Greenberger JS; Borisenko G; Belikova NA; Yanamala N; Samhan Arias AK; Tungekar MA; Jiang J; Tyurina YY; Ji J; Klein-Seetharaman J; Pitt BR; Shvedova AA; Bayir H Adv Drug Deliv Rev 2009[Nov]; 61 (14): 1375-85 PMID19716396show ga Effective regulation of highly compartmentalized production of reactive oxygen species and peroxidation reactions in mitochondria requires targeting of small molecule antioxidants and antioxidant enzymes into the organelles. This review describes recently developed approaches to mitochondrial targeting of small biologically active molecules based on: (i) preferential accumulation in mitochondria because of their hydrophobicity and positive charge (hydrophobic cations), (ii) binding with high affinity to an intra-mitochondrial constituent, and (iii) metabolic conversions by specific mitochondrial enzymes to reveal an active entity. In addition, targeted delivery of antioxidant enzymes via expression of leader sequences directing the proteins into mitochondria is considered. Examples of successful antioxidant and anti-apoptotic protection based on the ability of targeted cargoes to inhibit cytochrome c-catalyzed peroxidation of a mitochondria-specific phospholipid cardiolipin, in vitro and in vivo are presented. Particular emphasis is placed on the employment of triphenylphosphonium- and hemi-gramicidin S-moieties as two effective vehicles for mitochondrial delivery of antioxidants. |Animals[MESH] |Antioxidants/*pharmacology[MESH] |Apoptosis/drug effects[MESH] |Drug Delivery Systems/*methods[MESH] |Electron Transport Complex I/metabolism[MESH] |Free Radical Scavengers/*chemistry/pharmacokinetics[MESH] |Humans[MESH] |Mitochondria/drug effects/*metabolism[MESH] |Models, Biological[MESH] |Molecular Structure[MESH] |Oxidation-Reduction/drug effects[MESH] |Oxidative Stress/*drug effects[MESH]Mitochondrial targeting of electron scavenging antioxidants: Regulatio(epmc).pdf DeepDyve Pubget Overpricing